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MoonMama

HARMONY TEST (NIPT)

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MoonMama

Is anyone considering getting the Harmony test at 10 weeks?

 

I'm seriously thinking about it this time. For peace of mind that all is well and also to find out the gender early :secret::babyboy::babygirl:.

 

Have looked into it and it's about $450 and 2 x vials of blood drawn at 10 weeks. Results a few days after that.

 

Just wondering if anyone else is considering it?

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Caribou

Coming in from Recent discussions....

 

Not from August EDD, (April EDD) for me, and honestly apart from gender and piece of mind, it was damn worth it.

 

at my 20w ultrasound it was suspected the baby had a hole in his heart. If we hadn't had the NIPT, he would have also had been considered to potentially have chromosomal defects. because the NIPT considered him low risk for all chromosomal issues on the NIPT, the OB wasn't worried about that at all, so we were able to focus on just if the issue was a Congenital heart defect or not.

 

Long story short, it cut the investigating down heaps. in the end, the hole was not a CHD, but something else which shouldn't affect pregnancy.

 

Just had to jump in and say despite the cost, it picks up far more than a 12wk and a 20w scan can. Every bit of information about how your pregnancy is going helps, even if the results don't change the outcome of pregnancy for you, it gives you time to prepare for it at least!

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fever head

I'm thinking about it this time, the price seems to have come down considerably since I was pregnant with DD. Back then, I was told it would be around $700!

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ma.wright91

I had to look it up to see what it was! My GP just went over basics, ordered pathology tests & recommended a GP/OB in my current location to catch up with & talk specifics, so that will be Jan 3rd. Time seems to be dragging since that first positive test!

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loulou1985

I'm definitely going to get it! Want to be sure on gender as well as the trisomies

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ACT mum

I was an older mum, so it was a no brainer for me. Gave me peace of mind.

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Hazel87

I'm going to get NIPT done. It's still a screening test (not diagnostic) but it's accuracy is >99% compared to the 90% for first semester combined screening (FTCS). Most obstetricians still recommend getting the 12 weeks scan too as that shows other important info.

 

If your advanced maternal age it's a good idea to get NIPT as the FTCS often comes back high risk based on age alone.

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AshloBeans

We had the Harmony test last time and it was great to find out the gender early But we have decided not to this time round because it wouldn't change anything for us.

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Me - You

Just wanted to share that we had the Percept test rather than Harmony on recommendation of our specialist. It is done here in Aus so results are faster and costs less.

 

https://www.vcgs.org.au/tests/perceptnipt

 

We wanted to know gender as we hadn't had the chance with our previous pregnancies and being older it was great peace of mind.

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Demera

Also from the April group. At 38 with previous miscarriages, the Percept test was a no brainer for me also. It picked up a problem that we otherwise wouldn't have known about, which was followed up with further scans. There were three possible outcomes for the strange result, but the most likely (a vanishing twin) seems to have been the case as the follow up scans have all been well. It was worth getting.

 

Keep in mind that while it's very accurate for Downs, it's not super accurate for gender. False positives are fairly common when you google around a bit. In my case had they not been very thorough and cautious with the results, they could have said mine was a boy when it's actually a girl.

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MoonMama

Thanks @You + Me l have looked into the Percept test at your suggestion and think I'm going to get that one! :)

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CallMeFeral
We had the Harmony test last time and it was great to find out the gender early But we have decided not to this time round because it wouldn't change anything for us.

 

Sorry visitor to this are but just on this... wouldn't change anything is an interesting term. I know most people mean it to say they wouldn't abort if there was a problem. But in fact even if there is one, you are much better off forewarned so you know about it. A friend of ours had a baby with Downs, they knew beforehand and did so much research and were able to insist on the best possible treatments for him right from the start, when the hospital would have done things the old way as they don't see many of those babies anymore, even though what is now considered best practice is quite different to what it was.

 

I just wanted to point it out, as it made a huge difference to them, and to their son's welfare. Just something to consider.

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AshloBeans

Sorry visitor to this are but just on this... wouldn't change anything is an interesting term. I know most people mean it to say they wouldn't abort if there was a problem. But in fact even if there is one, you are much better off forewarned so you know about it. A friend of ours had a baby with Downs, they knew beforehand and did so much research and were able to insist on the best possible treatments for him right from the start, when the hospital would have done things the old way as they don't see many of those babies anymore, even though what is now considered best practice is quite different to what it was.

 

I just wanted to point it out, as it made a huge difference to them, and to their son's welfare. Just something to consider.

 

I understand what your saying. But, NIPT is only a screening test and a diagnosis couldn't be made with that alone. I wouldn't want to face the dilemma of whether to undergo invasive testing in the setting of a high risk result.

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Caribou

I understand what your saying. But, NIPT is only a screening test and a diagnosis couldn't be made with that alone. I wouldn't want to face the dilemma of whether to undergo invasive testing in the setting of a high risk result.

 

A visitor here too, sorry, but does that mean you also choose to opt out of the NT scan tests as well? Because both the NT and the NIPT are screening tests.

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AshloBeans

A visitor here too, sorry, but does that mean you also choose to opt out of the NT scan tests as well? Because both the NT and the NIPT are screening tests.

 

Of course - if I wanted aneuploidy screening, I would have NIPT, it is a better test. Given, I don't it wouldn't make sense to then choose to have a less effective screening test.

 

I'm still going to have a 12 week scan though (just not the NT or bloods).

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Caribou

but the NIPT is a more effective screening test than the NT. the NIPT also comes with a scan at 12 weeks too. They measure to make sure the baby is growing etc. that takes about 20-30 min scan around then.

 

Anyway, the choice of course, is up to the person, but ultimately the NIPT will be replacing the NT test. Even if it doesn't change the outcome for you in terms of results, it sure helps being better prepared. You'll be stressed out whether it's the NIPT or the NT.

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Wonderstruck

Not in this DIG but I think Ashlo meant just a growth/wellbeing scan at 12 weeks not testing for downs at all. This was recommended to me as I had genetic testing on my embryos for something else but also ruled out downs which was more accurate that NT and NIPT.

 

My OB wanted a scan at 12 weeks even though we weren't testing for downs, just to get a look at bubs. In that case they just won't to the NT measurement or bloods.

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snowflakedoll

I'm due August 3rd. I asked for the percept test from my GP today and he gave me the wrong referral form- only discovered this when I got home grr. He sent me home with the normal screening test form and wrote 'percept' on it. There's nowhere to put payment info!

 

Additionally he said the 12w ultrasound would be a waste of money because the NIPT test picks up everything.

 

From what I've read this is not true! Can anyone else confirm? Surely it's important to have the scan to see the babies structure? I asked this of my GP and he said that's what the 20w scan is for.

 

Obviously but if there's something that can be picked up at 12w instead of 20w wouldn't this be better for me?!

 

So confused.

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Hazel87

Usually a 12 week scan is offered as well. It can show important info such as a missed miscarriage, number of fetuses (if you haven't had a dating scan) and major structural abnormalities (eg brain, spine, heart). When you look at the percept info sheet it recommends NIPT + US or NIPT + The usual first trimester screening + US.

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kittn

Hi snowflakedoll - sorry to butt in when I'm not in your DIG (I'm a month ahead of you in July) but yeah, your GP is not quite right. The Harmony or Percept test can only test for Trisomies 13 (Patau), 18 (Edwards), 21 (Down), plus the sex chromosome disorders Turner or Klinefelter syndromes. Plus tell you the sex of the baby, of course.

 

There is another blood test (the combined first trimester screen) that they do in conjunction with the 12w scan to give you an overall risk assessment of having a baby with Down Syndrome, neural tube defects (e.g. spina bifida) as well as other possible complications like pre-eclampsia and so on. The 12w scan also checks for obvious structural defects such as anencephaly (a major neural tube defect where the skull and brain don't develop) which certainly isn't picked up by Percept. I can't imagine how awful it would be to have that discovered at 20w instead of 12w, which would be devastating enough.

 

Personally I wouldn't think it's a waste of money at all - but that's me wanting every opportunity to see bubs. :)

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snowflakedoll

Thanks guys really appreciate the responses. As I suspected, my GP is misinformed. So frustrating to be told wrong information.

 

I'll get the ultrasound scan around 12w first (as morbid as this sounds, to make sure bub is alive) and then get the percept test the same week once I have the correct form!

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~Bob~

Surely it's important to have the scan to see the babies structure? I asked this of my GP and he said that's what the 20w scan is for.

 

Obviously but if there's something that can be picked up at 12w instead of 20w wouldn't this be better for me?!

 

Don't worry about the percept form being wrong. It mostly matters when it's a Medicare item and they need it in case of an audit. Given that you are fully funding it, the form you have should suffice. Perhaps call them to double check.

 

They also perform a quick ultrasound before the NIPT to make sure you have a viable baby on board first. It's a quick scan, so it's not in place of anything else.

 

The current advice is that a 12 week anatomy scan is recommended. As others have said, it checks for major structural issues. If they find anything, they can still perform a D&C at this stage, whereas, if they find it at 20 weeks, you need to deliver. It's one of the main advantages of finding out earlier. For this, you need to ask for a referral for an anatomy scan. This referral needs to be correct for the Medicare portion.

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Megans21

Ok guys sorry board hopping just want to clear some things up. My daughter is 15 months old born with down syndrome. I did not screen at all nt or nipt and for my family it was the best choice. Not all families feel that they want preparation as they feel it will affect their pregnancy. Saying that if you do have a NIPT test done please be aware that while it is 99% sensitive it is NOT 99% accurate. As a matter of fact the american college of obgyn's states the positive predictive value (ppv) is as low as 33% in 25 year old mothers. Meaning if you got a positive result for t21 at age 25 then 67% of those positives are false positives. False positives for t13 in that age group are as high as 91%. The test is a fantastic screen but if you receive a positive result then you need to know that that is not 99% correct and that you would still need diagnostic testing like CVS or amnio to confirm.

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