[trdl]

So sorry for your losses

When you say "tests" have you had a pelvic ultrasound (not a normal US but inserting camera into vagina)? I have been trying for #2 for over 7 years and everyone kept saying they dont know what is wrong with me. I have recently found a great new doctor who sent me to have a pelvic ultrasound. I had one of these before but it wasn't picked up, so it might depend on the sonographer doing the US. In the recent scan they found i had a sub septate uterus. (you might have to google it) there are other names for it for the different abnormalities of the uterus. The one i have isnt that bad but im about to see another FS to find out if any of this is a reason why i cant conceive or why i have miscarried.

Your situation is probably so different to mine but just suggesting you might want ask to have a full pelvic ultrasound if you havent had one.

[my3beautifulboys]

Hi MaryAnne, Im so sorry that youre having to go through this, it must be so heartbreaking. I know how it feels after recently having my second recurrent miscarriage. It is so confusing and unfair. My doctor wants me to have further testing now before we try again, so really hoping that it will be successful.

I hope that you will be able to get some answers soon, perhaps from another specialist? I think that I am going to be refered to a Gynocologist for testing.

Sending you hugs and strengh, take care x

[zjb2]

Hi MaryanneK,

Sorry to hear about your losses.

I too had four recurrent miscarriages, so I understand the pain and confusion of multiple losses.

There can be many reasons for this to happen (and unfortunately sometimes no reason), and quite a few have been listed above.

I understand that you have been tested for a lot of things, but has your DH? The reason I ask is that we both had loads of tests after our third, all requested by the OB, and nothing really striking was found. Was referred on to a Fertility specialist who specialised in recurrent miscarriages and got tested for a heap more (bloods, genetic, scans, hysterscopy and the tube dye test for me with blood, genetics, SCSA for DH), and we actually found a number of things that could be contributing (and were each treated outside of IVF) but particularly there was a male infertility factor reason that was a main contributor. This was treated through IVF and after one further loss I am now 25 weeks pregnant.

My advice see an recurrent miscarriage expert (often through IVF centres) and if you would like a recommendation PM me.

Best of luck with your next steps.

[Mitchy's Mum]

I am so sorry you are going through this. I had 5 m/c's in a row over 4 years. At one point I thought I had been tested for absolutely everything, but it tunrs out there were still other tests that could be done. The best I can reccomend for you at this point, would be to find yourself a FS who specialises in recurrent m/c. They have all the info & tests you'll need.
My wonderful Ob, sent us to the m/c clinic at Sydney IVF, and then onto a Dr who is doing alot of groundbreaking research into recurrent m/c at IVF Australia. And our little miracle bub will be 1 year old next week.
Are you in Sydney by any chance Maryanne. If so I'll PM you some info.

Take care of yourself, and surround yourself with caring people.

[maryanneK]

thanks so much everyone, your replies are so nice to read

Most of the things you mentioned I have been tested for - including thyroid, genetics, internal ultrasound, structural/physical things with my uterus and lining, vitamins, etc

uterine lining and killer cells is a new one! And some of this; "hysterscopy and the tube dye test for me with blood, genetics, SCSA for DH), " - what does all that mean?

Am already seeing an infertility specialist, surely they should have enough experience in recurrent miscarriages to put me on to any more tests that need to be done?

anyone out there had recurrent miscarriages that just ended up being "bad luck" and had a successful pregnancy without changing anything?

thanks so much
x

[KeepTheFaith]

Hi Maryanne, I'm so sorry for what you have gone through. I know how rough it is. I have had 7 miscarriages and one live birth, and been thoroughly confused by all of the different 'suggestions' I have tried (aspirin, progesterone, PGD IVF etc) as to how to make bubs stick.

All my testing showed that DH and I were "normal".Well, apart from my PCOS, but hey, that's pretty 'normal' it seems, and not a reason to miscarry.

With my DD I did a combination of progesterone pessaries and Metformin (for the PCOS, and kept taking it throughout pregnancy on advice of FS). However, I then lost another 2 bubs on exactly the same 'formula'.

I am currently 20 weeks pregnant after a new OB (who worked at a leading London facility in recurrent miscarriage) suggested I try Pregnyl injections twice per week from week 4- week 14. Pregnyl is normally used to induce ovulation, but it can also be used to help women who have recurrent miscarriages in the 4-6 week time frame, where nothing seems to be 'wrong' but the baby doesn't stick. I have done my own research on the use of Pregnyl for this, and it seems that the jury is still out, but hey...it's working for me (I believe), and I am amazed that I have never heard of it before.

Maybe ask your FS about Pregnyl? It is basically a concentrated shot of hCG, the pregnancy hormone, taken from pregnant women's urine (sorry if TMI!). And some people swear by it.

Good luck with everything.

[zjb2]

Hi again OP,

Here are some slightly longer explanations:

Hysterscopy - procedure, usually done under GA, to confirm things like a septate uterus, fibroids and the presence/absence of uterine infections (which can be caused by prior miscarriages) and I believe it is possible, if your OB wants, to test the NK cells.

The Tube dye test - I can't remember the medical name. Basically a test to check that the fallopian tubes are open, and it can be used to check the uterine shape, done in a office.

Blood - By this I mean a huge raft of test, I think they took 12 vials from me to check for all sorts of things. I can't remember them all but I think they including testing for clotting diseases, insulin resistance, immune issues, etc

Genetics - a blood test to check that neither partner has a balance translocation, which can cause recurrent miscarriage

SCSA - a specific type of sperm analysis that tests lots of parameters but different to other tests looks for the level of dna fragmentation which can be a significant cause of miscarriages.

Hope that helps,
Zjb.

[Natttmumm]

So sorry u are going through this. I would suggest a miscarriage specialit. Ring one of the ivf clinics as they all have a specialist. They do a whole heap of tests and then you go through a program next time you are pregnant such as weekly blood tests and scans so they can see exactly what's happening. I hope this helps it helped us

[Satay chicken]

anyone out there had recurrent miscarriages that just ended up being "bad luck" and had a successful pregnancy without changing anything?

I asked my FS this and she said that yes, it can be bad luck.

But, definately also ask about NK cells (Here is a link to one of Australia's top Dr's in this field, you need to scroll down a bit : http://www.kareenaprivate.com.au/our-docto...ers%200910.pdf)

(This is a really informative thread by the way....)


Link didn't work - here is a different one : http://www.inciid.org/printpage.php?cat=im...logy&id=374

This post has been edited by Satay chicken: 02/05/2012, 12:37 PM

[Natttmumm]

Just wanted to add that some of the test results can change over time. I had a just positive result to one of the blood clotting antibodies so was given the treatment to that and have had 2 babies after reoccurring miscarriages. I have re tested since and results were negative. The FS explained its hard to find anything and results can change but worth a try with some of the medications and to be monitored. He told us that studies show just the monitoring alone can help.
I hope this helps a bit.