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4 miscarriages in a row
what now?

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#1 maryanneK

Posted 30 April 2012 - 08:43 PM

just had my 4th miscarriage in a row. TTC number 1.... tried for 8 months with nothing, then 4 m/c in 7 months. Cant believe I am now officially hanging out in this forum instead of the TTC forum  cry1.gif
all m/c at between 4 and 5 weeks. Been tested for everything under the sun and all come back normal.
how can I keep hoping? all tests keep saying there's nothing wrong but I've had 4 pregnancies and not one has lasted past 5 weeks...what am I meant to do?
so sad now.

#2 tibs

Posted 30 April 2012 - 08:46 PM

Sorry to hear about your losses sad.gif  I have had 3 myself, it sucks.

What is your Obs saying about it?  Have they put you on aspirin or any of the hormones to help?  Just wondering what you have tried.

#3 maryanneK

Posted 30 April 2012 - 08:50 PM

thanks xx
with this one they suggested maybe progesterone but when I got my HCG test at 3.5 weeks they also found that progesterone was fine
they did mention aspirin but the preg and then m/c happened so fast I didnt even get a chance to get on it. that and the fact they have already tested and ruled out any blood clotting disorders, seems that aspirin is unlikely to have helped
just so frustrated they keep saying nothings wrong but Ive had FOUR m/c. what the hell?!

#4 Satay Chicken

Posted 30 April 2012 - 08:55 PM

Have you had a uterine biopsy Maryanne?  This will check your lining and for uterine killer cells....

#5 Riotproof

Posted 30 April 2012 - 08:57 PM

Maryanne, I'm so sorry.

#6 Spring Chickadee

Posted 30 April 2012 - 09:00 PM

I am so sorry you are going through this. I had the same issue and lost all my pregnancies early. I will share what turned out to be the issue for me, not sure if it will help but it can't hurt.

I know you said you've been tested for everything, just to check does that include your thyroid (not all docs check this), this was one of my issues. My thyroid was slightly elevated, further testing revealed an autoimmune disease effecting my thyroid. This causes MC and preterm birth. I'm on thyroxine for this as well as a gluten and soy free diet and a number of supplements.

Has PCOS been ruled out? They usually only test for this if you aren't falling pregnant at all but some studies show women with PCOS has up to a 50% miscarriage rate. I went on metformin which has been shown to reduce that risk to normal. Metformin also improves your lining which is what you want for a more secure implantation.

FS's rarely test vitamin and other general levels, yet these can cause MC also. For me a very low vit D and high insulin levels may have both been contributing factors.

Progesterone- this is a little controversial as the jury is still out on if it works up it can only help to have extra progesterone support from after ovulation. I had a luteal phase issue and my progesterone levels are always on the low side. This pregnancy I was on the progesterone, maybe it helped maybe not, but ts worth not taking the risk.

I also see a fertility naturopath with a masters in endocrinology and human genetics. My diet was altered and I wet of a range of vitamins and minerals that are proven to improve lining quality, hormone regulation etc.

I'm now 13 weeks into my very healthy pregnancy.

I'm a shocker at remembering to revisit threads so pm me with any questions.

#7 seaside_feral

Posted 30 April 2012 - 09:07 PM

Maryanne I am so sorry to read your news - I have been following your journey for a while now and had high hopes for you when I read about your recent BFP.  

I don't really have any advice for you lovely, maybe you could ask for a referral to someone who specialises is treating recurrent miscarriage?

Sending you strength and hugs.  

#8 libbylu

Posted 30 April 2012 - 09:17 PM

I am so sorry about your losses.
My cousin had 4 miscarriages and nothing came out in the tests.  In the end she did IVF. The first was a miscarriage or chemical pregnancy, the second transfer stuck and they are now about 5 months in with a healthy pregnancy. I am not sure if they did pre-implantation genetic diagnosis - I know this can be an option for some people.

#9 faithy

Posted 30 April 2012 - 09:36 PM

Hi MaryanneK,

So sorry to hear what you're going through - it's heart breaking and is emotionally/physically exhausting.

Over 3 years I've had 9 miscarriages (<9 wks) ... did all the tests and everything came back 'fine' including the blood clotting.

As there was no reason why me and DH couldnt conceive our FS decided to 'try' the aspirin, as well as progesterone injections, to see what happens.

Lo' and behold I fell pregnant... again... and this time it 'stuck'. I'm currently 33 weeks and can hardly believe it.. still feels surreal sometimes. Whether it was prayers or the combination of the above who knows. I guess we'll find out when/if we try for #2

Good luck and praying all works out for you.

Edited by faithy, 30 April 2012 - 09:37 PM.

#10 dizzy-anne

Posted 30 April 2012 - 10:07 PM

Hi Maryanne, so sorry you are going through this.  I hope you are being kind to yourself.  Don't rule out aspirin because your blood clotting results were fine - my sister actually had a blood clot and they could find no reason why.  I went on aspirin after my 3rd miscarriage and carried to term - not saying that was the key, it may have just been luck, but my FS said that it can't hurt... so I tried it.  I hope you have some luck soon, I know how heartbreaking it is.  Big hugs.

Edited by dizzy-anne, 30 April 2012 - 10:07 PM.

#11 trdl

Posted 30 April 2012 - 10:24 PM

So sorry for your losses

When you say "tests" have you had a pelvic ultrasound (not a normal US but inserting camera into vagina)? I have been trying for #2 for over 7 years and everyone kept saying they dont know what is wrong with me. I have recently found a great new doctor who sent me to have a pelvic ultrasound. I had one of these before but it wasn't picked up, so it might depend on the sonographer doing the US. In the recent scan they found i had a sub septate uterus. (you might have to google it) there are other names for it for the different abnormalities of the uterus. The one i have isnt that bad but im about to see another FS to find out if any of this is a reason why i cant conceive or why i have miscarried.

Your situation is probably so different to mine but just suggesting you might want ask to have a full pelvic ultrasound if you havent had one.

#12 my4beautifulboys

Posted 30 April 2012 - 10:38 PM

Hi MaryAnne, Im so sorry that youre having to go through this, it must be so heartbreaking. I know how it feels after recently having my second recurrent miscarriage. It is so confusing and unfair. My doctor wants me to have further testing now before we try again, so really hoping that it will be successful.

I hope that you will be able to get some answers soon, perhaps from another specialist? I think that I am going to be refered to a Gynocologist for testing.

Sending you hugs and strengh, take care x

#13 zjb2

Posted 01 May 2012 - 08:28 AM

Hi MaryanneK,

Sorry to hear about your losses.

I too had four recurrent miscarriages, so I understand the pain and confusion of multiple losses.

There can be many reasons for this to happen (and unfortunately sometimes no reason), and quite a few have been listed above.

I understand that you have been tested for a lot of things, but has your DH? The reason I ask is that we both had loads of tests after our third, all requested by the OB, and nothing really striking was found. Was referred on to a Fertility specialist who specialised in recurrent miscarriages and got tested for a heap more (bloods, genetic, scans, hysterscopy and the tube dye test for me with blood, genetics, SCSA for DH), and we actually found a number of things that could be contributing (and were each treated outside of IVF) but particularly there was a male infertility factor reason that was a main contributor. This was treated through IVF and after one further loss I am now 25 weeks pregnant.

My advice see an recurrent miscarriage expert (often through IVF centres) and if you would like a recommendation PM me.

Best of luck with your next steps.

#14 LeeBee8

Posted 01 May 2012 - 02:51 PM

I am so sorry you are going through this. I had 5 m/c's in a row over 4 years. At one point I thought I had been tested for absolutely everything, but it tunrs out there were still other tests that could be done. The best I can reccomend for you at this point, would be to find yourself a FS who specialises in recurrent m/c. They have all the info & tests you'll need.
My wonderful Ob, sent us to the m/c clinic at Sydney IVF, and then onto a Dr who is doing alot of groundbreaking research into recurrent m/c at IVF Australia. And our little miracle bub will be 1 year old next week.
Are you in Sydney by any chance Maryanne. If so I'll PM you some info.

Take care of yourself, and surround yourself with caring people.

#15 maryanneK

Posted 01 May 2012 - 08:57 PM

thanks so much everyone, your replies are so nice to read

Most of the things you mentioned I have been tested for - including thyroid, genetics, internal ultrasound, structural/physical things with my uterus and lining, vitamins, etc

uterine lining and killer cells is a new one! And some of this; "hysterscopy and the tube dye test for me with blood, genetics, SCSA for DH), "  - what does all that mean?

Am already seeing an infertility specialist, surely they should have enough experience in recurrent miscarriages to put me on to any more tests that need to be done?

anyone out there had recurrent miscarriages that just ended up being "bad luck" and had a successful pregnancy without changing anything?

thanks so much

#16 Dawarr

Posted 01 May 2012 - 09:13 PM

Hi Maryanne, I'm so sorry for what you have gone through. I know how rough it is. I have had 7 miscarriages and one live birth, and been thoroughly confused by all of the different 'suggestions' I have tried (aspirin, progesterone, PGD IVF etc) as to how to make bubs stick.

All my testing showed that DH and I were "normal".Well, apart from my PCOS, but hey, that's pretty 'normal' it seems, and not a reason to miscarry.

With my DD I did a combination of progesterone pessaries and Metformin (for the PCOS, and kept taking it throughout pregnancy on advice of FS). However, I then lost another 2 bubs on exactly the same 'formula'.

I am currently 20 weeks pregnant after a new OB (who worked at a leading London facility in recurrent miscarriage) suggested I try Pregnyl injections twice per week from week 4- week 14. Pregnyl is normally used to induce ovulation, but it can also be used to help women who have recurrent miscarriages in the 4-6 week time frame, where nothing seems to be 'wrong' but the baby doesn't stick. I have done my own research on the use of Pregnyl for this, and it seems that the jury is still out, but hey...it's working for me (I believe), and I am amazed that I have never heard of it before.

Maybe ask your FS about Pregnyl?  It is basically a concentrated shot of hCG, the pregnancy hormone, taken from pregnant women's urine (sorry if TMI!). And some people swear by it.

Good luck with everything.

#17 zjb2

Posted 02 May 2012 - 12:26 PM

Hi again OP,

Here are some slightly longer explanations:

Hysterscopy - procedure, usually done under GA, to confirm things like a septate uterus, fibroids and the presence/absence of uterine infections (which can be caused by prior miscarriages) and I believe it is possible, if your OB wants, to test the NK cells.

The Tube dye test - I can't remember the medical name. Basically a test to check that the fallopian tubes are open, and it can be used to check the uterine shape, done in a office.

Blood - By this I mean a huge raft of test, I think they took 12 vials from me to check for all sorts of things. I can't remember them all but I think they including testing for clotting diseases, insulin resistance, immune issues, etc

Genetics - a blood test to check that neither partner has a balance translocation, which can cause recurrent miscarriage

SCSA - a specific type of sperm analysis that tests lots of parameters but different to other tests looks for the level of dna fragmentation which can be a significant cause of miscarriages.

Hope that helps,

#18 Natttmumm

Posted 02 May 2012 - 12:32 PM

So sorry u are going through this. I would suggest a miscarriage specialit. Ring one of the ivf clinics as they all have a specialist. They do a whole heap of tests and then you go through a program next time you are pregnant such as weekly blood tests and scans so they can see exactly what's happening. I hope this helps it helped us

#19 Satay Chicken

Posted 02 May 2012 - 12:35 PM

QUOTE (maryanneK @ 01/05/2012, 08:57 PM) <{POST_SNAPBACK}>
anyone out there had recurrent miscarriages that just ended up being "bad luck" and had a successful pregnancy without changing anything?

I asked my FS this and she said that yes, it can be bad luck.  

But, definately also ask about NK cells (Here is a link to one of Australia's top Dr's in this field, you need to scroll down a bit : http://www.kareenapr......ers 0910.pdf)

(This is a really informative thread by the way....)

Link didn't work - here is a different one : http://www.inciid.org/printpage.php?cat=im...logy&id=374

Edited by Satay chicken, 02 May 2012 - 12:37 PM.

#20 Natttmumm

Posted 02 May 2012 - 08:00 PM

Just wanted to add that some of the test results can change over time. I had a just positive result to one of the blood clotting antibodies so was given the treatment to that and have had 2 babies after reoccurring miscarriages. I have re tested since and results were negative. The FS explained its hard to find anything and results can change but worth a try with some of the medications and to be monitored. He told us that studies show just the monitoring alone can help.
I hope this helps a bit.

#21 oceangal

Posted 25 May 2012 - 09:47 PM

So sorry to read about your losses, it is a devastating experience. I had 8 m/c's in a row trying to conceive bub no 2. Every pregnancy became shorter in duration as the bub just wouldn't "stick".

The first tests I had done were bloods and the tube dye test, both of which came back fine. It was only after m/c #8 that my FS booked me in for a hysterscopy and a D & C. It was also advised that I keep a supply of progesterone pessaries and clexane to take immediately should I fall pregnant again.

The hysterscopy results were fine and about 6 weeks later I discovered that I was pregnant again. I took the pessaries and had the clexane injection literally within minutes of discovering I was pregnant.  I am currently 36 weeks with this bub and none the wiser as to the cause of the 8 m/c's.

I hope some good luck comes your way.

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