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high HCG level and increased DS risk?
another worry

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#1 brighton

Posted 11 July 2011 - 03:00 PM

hi ladies

I;m 8 weeks, 3 days just had bloods and scan today (all good).

However, reading the literature for the NT scan it seems there is a link between high HCG levels and increased risk for DS or other chromosomal issues.

My bloods have come back at 178,000 which are at the top of the scale for 8 weeks. so freaking out about something else now!

Does anyone know HOW high is "higher risk" or are my levels just at the top of the range? would they consider higher than this to be worryingly high?

thanking you all in advance for any info or reassurance, good or bad.

sarah x

#2 mylittlemen

Posted 11 July 2011 - 03:32 PM

I don't know how high the levels need to be, however, I got a high risk DS result at 12 weeks (1 in 85), put down by the drs to high HCG levels.  My HCGb MOM was 2.10.  (My NT measurement was also 2.3 and I am 36).  The drs did tell me while the high HCG gave me a statistically higher risk of DS, they had personally never seen it mean DS without lower PAPP-A as well (mine was pretty much on the average).  However, they couldn't give me any certainty.

I don't know how high my HCG levels were before 12 weeks as they don't test this (rely on HPTs) in the country I live in.

I had an amnio and got the all clear.

Interestingly, my scans since 19 weeks suggest the baby is very large (measuring 4-5 weeks ahead and I don't have GD).  I have no idea if there is any link though.

#3 Xiola

Posted 11 July 2011 - 04:36 PM

The high HCG needs to be taken into consideration with your PAPP-A level is as the pp said.  Those bloods are taken at 10 weeks and combined with your NT measurement along with your age, bubs heartbeat and various other things.  At 10 weeks my HCG was a bit low as was my PAPP-A which gave me a crazy risk for T18 and T13 but an amnio has shown that everything is fine.

At 8 weeks I wouldn't be worried about it.

#4 ~~HappyMummy~~

Posted 11 July 2011 - 06:50 PM

I had a high risk for downs also due to high HCG levels (1:154).   Had an amnio and all was fine.   The high HCG levels also made me really really sick with morning sickness.......   I hope the same doesn't happen to you!!

Edited by ~ jen ~, 11 July 2011 - 06:50 PM.

#5 Tetinks

Posted 11 July 2011 - 07:03 PM

I had high HCG levels and increased risk of DS too.

There is no 'range' as such, HCG (and papp-A) is measured in MoM, or Multiples of the Median. So this means the median HCH level is recorded as 1.0. A HCG result of 2 means your HCG is double the median.

They 'like' the HCG to be at 2 or below. Mine was 2.2(ish? can't remember now) for this pregnancy which led to increased risk. However, the HCG is the least significant of the three factors that makes up your DS risk (the other two being the NT measurement and the papp-A result).

I think really high HCG is much more of a concern when combined with low papp-A and/or a large NT measurement.

In my reading I discovered that high HCG can also mean a large placenta and larger baby, and it's much more common in female babies.

ETA: here's a topic I started on the same subject after my 12 week screening.


Edited by claireabell, 11 July 2011 - 07:05 PM.

#6 alybel

Posted 11 July 2011 - 10:24 PM

Also, the NT risk bloods measure free beta-hCG.  The blood test you would have just done is the total beta-hCG so they really can't be compared.

#7 brighton

Posted 12 July 2011 - 08:44 AM

thanks so much ladies, I feel much more informed now and as ever you have all been really helpful.

I will be sitting tight and trying not to have another freak out before I actually need to!

thanks again xx

#8 Phascogale

Posted 12 July 2011 - 11:07 AM

High hcG levels are also linked to twins.

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