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Anyone had a higher than expected DS risk at 12 weeks due to high HCG levels?


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#1 Tetinks

Posted 21 March 2011 - 04:49 PM

Hi

Hope my title made sense...

I am just over 14 weeks with baby #3. I had my NT scan last week at 13+2 and it all looked great - NT thickness was 1.5mm, we saw a nasal bone and the development is all on track - nothing unusual.

I saw my ob today and frustratingly, the lab sent him my blood results but have not yet provided a risk assessment as the software they use isn't working ( rolleyes.gif  don't even get me started on that!).

But he said that going by my blood results, I can probably expect a higher than expected risk. He said he wasn't too concerned, but not to expect a very low risk like I had with my older kids.

My PAPP-A was .78mom
My hCG was 2.15mom.

So the PAPP-A levels are okay, physically the baby looks okay, but my HCG is quite a bit higher than they would like.

I'm just wondering if anyone else has experienced this? What was your risk? I will hopefully get my combined risk tomorrow and will obviously decide then whether or not to get further testing. FWIW my hcg levels were very high in early pregnancy too - about 4-5 times the average on betabase.

Also, does anyone know why the hcg could be so high at this stage of pregnancy? Obviously Down Syndrome is a possible cause, but is there anything else?

Cheers.

#2 mylittlemen

Posted 21 March 2011 - 04:57 PM

Me.

My NT measurement was 2.3mm (so higher than yours but within the 'normal' range), my PappA was a shade over 1 (so normal) and my BHCG was a bit over 2 (I can't remember exactly now but about what yours is).

I got a 1 in 85 risk of DS (I will also be 36 when this baby is born).  I went on to have an amnio and have received the all clear.  My dr told me that while she could give me no certainty, her view was that it would be VERY unusual to be the 1 in the 85 if it was only based on elevated BHCG.  I was told the 'norm' was to have elevated BHCG and lower PappA as well.  However, this is a statistical test so you can't ever be sure one way or the other.

I did some google research and from what I could see, there is a slightly greater chance you are having a girl if you have an elevated BHCG at the NT scan time (although take that with a grain of salt as it was google research).  I couldn't find any other reason for it.

I do wonder if the elevated level was what caused my morning sickness to last until 20 weeks (vs about 13 weeks with DS).

Sorry you are going through this.  It was a very stressful time for DH and I.

#3 mylittlemen

Posted 21 March 2011 - 05:27 PM

While you are waiting for your results, you might want to have a play with the tool here:

http://www.sbpsoftware.com/trisomy-risk-calculator.html

However, please note that I was linked to it through another forum and everyone on that forum who used it (myself included) got better results using that tool than the official results we were given (not by much though) so don't be shocked if your official result is a bit 'worse'.  From what we could see, it depends on how the software weights the importance of the NT measurement vs. the blood test results.

Also, it may be completely unrelated but at 22 weeks, this baby is very large.  I have had a scan at 19 weeks which showed over 100 percentile on all measurements so had to have a GD check (came back all clear) and a further detailed scan with a specialist.  This confirmed the measurements (very large baby tracking nicely on its own curve for size - still over 100 percentile across the board) but there is no reason for it - they just think we've made a big baby this time (DS was 4.1kg so not exactly tiny and it may be my 2nd baby is bigger).

#4 TheSmithFamily

Posted 21 March 2011 - 05:37 PM

Hi there,

For my second pregnancy I got a high risk  1;99 but my fold was 3.2 and my bloods were around 2 for each reading.

After the amnio was all clear I had 2 scans at 20 and 22 weeks so they could do a very detailed heart scan as sometimes bloods can reflect an issue here, fwiw it was also a girl. all was okay.

Take care and I hope the results you get ease your mind at this stressful time.

Bron

#5 Angelina Ballerina

Posted 21 March 2011 - 05:50 PM

QUOTE (Expat2 @ 21/03/2011, 05:27 PM) <{POST_SNAPBACK}>
While you are waiting for your results, you might want to have a play with the tool here:

http://www.sbpsoftware.com/trisomy-risk-calculator.html

However, please note that I was linked to it through another forum and everyone on that forum who used it (myself included) got better results using that tool than the official results we were given (not by much though) so don't be shocked if your official result is a bit 'worse'.  From what we could see, it depends on how the software weights the importance of the NT measurement vs. the blood test results.

A



When I added 3 years to my age it was close to my actual results. It states the age risk as much lower than on my actual report

#6 Tetinks

Posted 21 March 2011 - 09:04 PM

Thanks everyone

I am feeling calmer about it all but very curious to get my combined risk assessment tomorrow. That link was interesting too.
QUOTE
My dr told me that while she could give me no certainty, her view was that it would be VERY unusual to be the 1 in the 85 if it was only based on elevated BHCG.

This is kind of what my dr said too... that the HCG was the least significant of the three results.

Will update tomorrow, hopefully.

#7 mrsmag09

Posted 22 March 2011 - 08:31 AM

Hi claireabell

When I had my nt scan at exactly 12 weeks, I was given a 1:460 risk of DS. This was based mostly on my very high hcg (almost 4!) because my papp-a was around 0.75 and the nuchal fold was 1.4mm. All my scans have looked normal since then so we are all HOPING and praying that the baby is ok. We decided against any invasive testing, but not a day goes by when I don't think about it...

Good luck with your results



#8 ~Sh3ekY M0nKeY TaMeR~

Posted 22 March 2011 - 08:38 AM

I am 29 my NT measurement was 2.7 my bloods were not unlike yours and I got a 1:27. An amnio has since proven there are no problems.

#9 Jessminder

Posted 22 March 2011 - 12:10 PM

Hi Clarebell,

My 12 week results are quite similar to yours -

NT - 1.60
Pappa A - 0.80
hCG - 2.36

However, my overall risk for DS came in a 1:6501, which suprised me because it was lower than my risk with DD 2 years ago. The Dr who performed the scan did mention that my hCG was higher than normal but he said that in isolation this doesn't cause any concern. I did have a missed mc the month before we conceived so I don't know if that contributed to the elevated levels.

Good luck for today.

#10 Tetinks

Posted 22 March 2011 - 04:49 PM

Thanks everyone

I got my risk today and it's 1:825, so not as 'good' as with my older 2 but still much better than I was expecting.

Jessminder I wonder why our risks are so different when our results are so similar. I see from your sig we are about the same age too (I will be 33 when this one is born).

#11 Jessminder

Posted 23 March 2011 - 12:41 PM

That's a very good question Clairebell. I would have thought that I would have a higher risk than you due to my hCG and NT being slightly higher. I had my scan done in the UK at the Fetal Medical Centre in London and they also take into consideration blood flow through a valve in the liver and the heart. I'm not sure if these factors are used over here but that is the only thing I can attribute to the difference in our overall results.






#12 Angelina Ballerina

Posted 23 March 2011 - 02:01 PM

claireabell that's great that you ended up with a low risk result after all




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