Jump to content

Balanced Translocation
Successful Conception (either naturally or assisted) is it possible??


  • Please log in to reply
10 replies to this topic

#1 WarriorWoman

Posted 02 December 2010 - 08:54 PM

Hi,

I am asking on behalf of a friend who has just found out she has a Balanced Translocation and who has been TTC for a while now. Is there anyone in EB land who has this condition or knows of someone with this condition who has had success conceiving?

I am just about to go and do a bit of online research as I am not too sure what it actually is, but she is looking for some info and I thought that this would be a good place to start. I have advised that she sign up herself, but I also hope to be able to offer her some immediate support and this is where you all come in.

I may have posted this in the wrong section, if so, sorry. I would appreciate any info from anyone.

#2 sebela

Posted 02 December 2010 - 08:58 PM

Julia has three kids now - but had a LONG battle with her DHs balanced translocation. Read the archives of her blog:

http://julia.typepad.com/julia/

#3 Feral_RosieC

Posted 02 December 2010 - 09:03 PM

Hi .

I have a balanced translocation.  Didn't find out until after I had conceived my son (first attempt) and then had 4 miscarriages before testing.  After testing I went on to have another 5 miscarriages before using IVF and PGD to conceive our DD.

If she is wanting some info, there is a PGD thread in the AC Buddy Groups section. It had been quiet for a while but there is some activity in there again.

I wish your friend well.

Edited by rosiec, 02 December 2010 - 09:12 PM.


#4 emc002

Posted 02 December 2010 - 09:04 PM

My Brother and SIL had this problem.

My brother has the balanced translocation but his sperm are unbalanced.  Wikipedia has the best articles about that side of things.  Basically the person has a balanced translocation and they are a surviving person, but the reproduction side makes them infertile, basically.

I think they may have conceived naturally, one time?  Then they had numerous rounds of IVF, before SIL requested further testing for both of them, which at the time, everyone was advising her was unnecessary.  Poor SIL had loads of miscarriages before or around 6 weeks, through some of these.

I think there was some little prob with SIL eggs, but it was my brother with the main prob as above.

Then they did quite a few PGD rounds, which is kind of like the technology used in the movie Gattaca, and the embryos got sent to Melbourne for screening.

Then they decided to pursue adoption, but then the country's waiting list which they'd just got onto, closed.

They then decided to go back to IVF this year, and using donor sperm.

Well, I will be an Auntie in January!!  She is 32 weeks.

So unfortunately, imho, maybe your friend could look at the donor egg side of things, to somehow get on the waiting list for that, before doing PGD.

However I'm sure someone else here has more experience with it all.

#5 niksia

Posted 02 December 2010 - 09:10 PM

We didn't end up having this thankfully, but were tested after our 2nd or 3rd miscarriage. Basically instead of having 2 sets of chronological chromosomes. In this case one or several are mixed up but still have 2 complete sets, so everything works normally. ie i set has 2 x #8 but no #5 the other set has 2 x #5 but no #8.

The implication for pregnancy is that each parent contributes a set of chromosomes. So if the one with defective (for want of a better word) chromosomes puts across the first set the baby would have 3 x #8  and 1 x #5. Therefore incompatible with life (gee I hate that term) and would miscarry.

We went through recurrent miscarriages all with major chromosomal mixups.

I believe IVF with genetic testing may be an option, but I could be wrong, it has been a while since I looked into it after the possibility was ruled out

#6 WarriorWoman

Posted 02 December 2010 - 09:14 PM

Thanks to those who have replied so far. Please keep the replies coming. I have sent my friend a link to this thread. It is nice to see there is hope out there and all is not lost.

#7 Angelina Ballerina

Posted 03 December 2010 - 10:31 AM

Just looked it up in my old genetics textbook. If a parent has a balanced translocation there is a 1 in 6 chance that the conceived fetus will be genetically normal, a 1 in 6 chance that the fetus will carry a balanced translocation (like mum) and 50% chance of abnormal genetic combinations that are unviable (depending on the translocation may be a 1 in 6 chance of live birth with genetic abnormality eg Down syndrome)

#8 AnZ

Posted 03 December 2010 - 10:44 AM

I have no information to contribute but I just want to say good luck to your friend I hope that everything works out for her and hope to hear good news on her in the near future.

#9 Kylie : )

Posted 22 November 2012 - 04:11 AM

Hi, I am 35 and have a balanced translocation 13:15 we were successful after our first attempt at IVF ICSI. Our son is also a balanced translcation like me. I am currently 3.5 months pregnant (fell naturally) and second baby is also a balanced translocation like me. Good luck and stay positive it can happen!  original.gif

#10 iwanttosleepin

Posted 22 November 2012 - 04:32 AM

My friend has a balanced translocation.  She has 2 children.

The oldest has an unbalanced translocation and major issues.  She has a moderate/severe intellectual disability and quite a few physical issues including low muscle tone, facial features, hearing loss, short stature etc.

Her younger son has a balanced translocation and no issues whatsover.

She had no issues getting pregnant.

Her sister has had recurrent miscarriages but has had 2 healthy children.  I don't think she has been genetically tested.

The child with a disability was part of a research thesis so a lot of time was spent finding the genetic issue and where it came from.

#11 c_shell

Posted 26 November 2012 - 05:12 AM

Please tell your friend to be careful and seek advice - yes you can conceive naturally with a balanced translocation but you have a larger risk for having a child with chromosome deletions and big issues. It would be wise to inform yourself about these risks.  I'm sorry to mention this.
Simply put, each chromosom has 2 arms and these arms can be swapped (translocate) between chromosomes. When someone with a translocation has children, they can pass the translocation onto their child, or the tranlsocation can result in extra or missing genetic material on one or more of the chromosome arms. These are probably the fetuses with chromosomal problems that are misscarried. Someone with a translocation can have some medical issues themselves, duplications also results in some issues and deletions generally alot more.

My DD has a significant chromosome deletion and she's one of the lucky ones whos mostly ok (short statured, some blood problems at birth), but I read every day in a facebook group for children with unusual chromosome deletions - nearly all of these children have global development delays and a range of health issues. DD's case is actually spontaneous (neither DH nor I have any unusual chromosomes), but many of the cases I know of come from parents with translocaitons.  

Try www.rarechromo.org  - this is a non-profit foundation for people with rare chromosome diagnoses . There is lots of excellent information about unusual chromosome issues. They might be able to help you more with actual numbers regarding what the risks are and put you in contact with people with similar diagnoses. I really hope things work out for you..  

"The effects of rare chromosomal disorders can be very varied. The vast majority of carriers of balanced rearrangements will have no symptoms but might have problems in reproduction.  "


0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users

 

The popular baby name from the Rio Olympics

"With a pair of athletes who are not only successful, but seen as great role models – combined with a softer sound – it is like hitting the jackpot."

Toy stuck in baby's throat for two weeks

When Jude Atiga's baby son Laith was struggling to breathe the worried mum called an ambulance.

Mum awarded $20 million over birth power struggle with nurses

As a mother of three, Caroline Malatesta thought she knew what she was letting herself in for when it came to the birth of her fourth baby.

Win a Baby Jogger City Premier for Father's Day

To celebrate Father's Day, one lucky EB fan will win one of their own! Enter Now!

'There's a giant picture of BOOBS but I can not feed my child'

A mum was ushered out of an US department store's underwear section after discreetly breastfeeding her baby.

Why fatherhood scares many dads-to-be

Travis Bull vividly remembers discovering his partner was pregnant for the first time.

Free ticket offer

Pinky Mckay joins us again at the Essential Baby & Toddler Show presented by Blackmores with her expert baby settling advice. Register now for your free ticket.

Warning for pregnant women as flu-related deaths triple

A more than three-fold increase in flu-related deaths has sparked a plea for those with the flu to stay away from vulnerable people.

I'm trying to keep my child-free friends in my life, but it's tough

I tried to prove to my single friends that I was the same I'd always been. But marriage did change me - and motherhood has, too

For the festival lover in all of us

Pre-book & Save 50%. Get your tickets now for Kidtopia Festival. 7-9 October 2016 Parramatta Park, Sydney.

Too many parents still putting babies in unsafe bedding: study

A study found that a whopping 91 per cent of four-week-old babies had been placed in cots with unsafe bedding.

Mum's shock as toddler fat-shamed by internet trolls

When a mother uploaded a cute photograph of her 14-month old child online, she did not expect a swarm of internet trolls to write that her toddler was fat.

How an Aldi staff member made one exhausted mum's day

It was a simple act of kindness, but one that made an exhausted mother's day.

The most awww-worthy celeb baby pics of the week

It's been a pretty cute week on Instagram in terms of celebs relishing their babies.

When 'Just Do It' just doesn't cut it

When even Michelle Bridges admits to struggling with her exercise regime, it's time to accept that having small children can be a legitimate reason for exercise not happening.

What life is really like when you have five kids

Life is cute with one, manageable with three, but at times completely impossible with five.

When no one can pronounce your baby's name

In Wales it's a common name, but over here, it's cause for some confusion.

Dad shares horror tale after Roomba's run-in with dog poop

It's the poop story that's been shared hundreds of thousands of times around the world.

How a homemade wheelchair is giving baby Evelyn freedom

Like all one-year-olds, Evelyn Moore is keen to get moving and explore the world around her. But a battle with aggressive cancer left the little girl paralysed from the waist down.

Single to double pram that folds with seat attached

A pram is a large purchase, and you only want to buy once.

Mum-to-be surprises husband with big news in joy-filled photoshoot

When Bri Dow learnt that she was expecting, she immediately knew she wanted to break the news to her husband Brandon in a special way.

Blake Lively: 'Post-pregnancy slim down pressure is so unfair'

Blake Lively has urged women not to feel pressured to lose weight after pregnancy.

 
Advertisement
 

Top 5 Articles

Advertisement
 
 
 

What's hot on EB

For the festival lover in all of us

Pre-book & Save 50%. Get your tickets now for Kidtopia Festival. 7-9 October 2016 Parramatta Park, Sydney.

Why drinking water can be deadly for babies

H2O is one of the necessities of life, but for babies a seemingly harmless amount of water can be fatal.

5 ways having a baby is different when you have older children

So much parenting advice is geared towards having your first baby, but what's it like having a baby when you already have children?

You can now make your own plush Falkor

Fans of The NeverEnding Story – of which there are certainly plenty – went crazy for these plush Falkors when they first went on sale last year.

Baby steps

10 things that will actually happen after having a baby

I thought I had prepared myself for motherhood. Then my baby girl arrived and knocked everything flat.

Having a baby: expectations vs reality

People love to warn you about what to expect when having a baby, but they can be way off when it comes to the reality.

Are we having fun yet? Thinking positively as a parent

Motherhood is wonderful ... except when it sucks.

The adorable smile of a baby seeing his mum clearly for the first time

There is no doubt seeing their child smile for the first time is an unforgettable moment for parents everywhere.

When breastfeeding doesn't go with the flow

Breast is best, except when it's not. And in our case, it most definitely wasn't.

'If you don't vaccinate your kids you're a bloody idiot'

The photos are heartbreaking and almost too difficult to look at, but Kayley Burke is begging other parents to take notice.

Why pregnant women should eat chocolate

In news that will make expectant mums jump for joy - and reach for a block of Cadbury - scientists have revealed chocolate could provide health benefits during pregnancy.

The baby born with an incredible head of hair

If you're in any way challenged in the follicle department, prepare to feel a jolt of envy - at a two-month-old baby.

The push for Medicare to fund lactation consultants

While meeting with a lactation consultant can make an enormous difference to a new mother, it's not a service that is available through the public health system.

Parents, this is how to cut grapes to avoid choking

One mum has learnt a harrowing lesson about the best way to cut grapes to make it safe for toddlers and little kids to eat.

Three truths about C-section mums

Lately I've been thinking about the caesarean stories and the brave women who birth their children with strength and beauty.

Help! My baby will only sleep in my arms

It's stressful to be the one who is holding your baby most of the day, but it's even more stressful to wonder, 'am I doing something wrong? Or am I creating bad habits?'

 

ENTER NOW

Win one of two Father's Day Gift Packs

Sign up to receive our new Essential Kids announcements emails for a chance to win.

 
Advertisement
 
 
Essential Baby and Essential Kids is the place to find parenting information and parenting support relating to conception, pregnancy, birth, babies, toddlers, kids, maternity, family budgeting, family travel, nutrition and wellbeing, family entertainment, kids entertainment, tips for the family home, child-friendly recipes and parenting. Try our pregnancy due date calculator to determine your due date, or our ovulation calculator to predict ovulation and your fertile period. Our pregnancy week by week guide shows your baby's stages of development. Access our very active mum's discussion groups in the Essential Baby forums or the Essential Kids forums to talk to mums about conception, pregnancy, birth, babies, toddlers, kids and parenting lifestyle. Essential Baby also offers a baby names database of more than 22,000 baby names, popular baby names, boys' names, girls' names and baby names advice in our baby names forum. Essential Kids features a range of free printable worksheets for kids from preschool years through to primary school years. For the latest baby clothes, maternity clothes, maternity accessories, toddler products, kids toys and kids clothing, breastfeeding and other parenting resources, check out Essential Baby and Essential Kids.