Successful Conception (either naturally or assisted) is it possible??
, Dec 02 2010 08:54 PM
10 replies to this topic
Posted 02 December 2010 - 08:54 PM
I am asking on behalf of a friend who has just found out she has a Balanced Translocation and who has been TTC for a while now. Is there anyone in EB land who has this condition or knows of someone with this condition who has had success conceiving?
I am just about to go and do a bit of online research as I am not too sure what it actually is, but she is looking for some info and I thought that this would be a good place to start. I have advised that she sign up herself, but I also hope to be able to offer her some immediate support and this is where you all come in.
I may have posted this in the wrong section, if so, sorry. I would appreciate any info from anyone.
Posted 02 December 2010 - 08:58 PM
Julia has three kids now - but had a LONG battle with her DHs balanced translocation. Read the archives of her blog:http://julia.typepad.com/julia/
Posted 02 December 2010 - 09:03 PM
I have a balanced translocation. Didn't find out until after I had conceived my son (first attempt) and then had 4 miscarriages before testing. After testing I went on to have another 5 miscarriages before using IVF and PGD to conceive our DD.
If she is wanting some info, there is a PGD thread in the AC Buddy Groups section. It had been quiet for a while but there is some activity in there again.
I wish your friend well.
Edited by rosiec, 02 December 2010 - 09:12 PM.
Posted 02 December 2010 - 09:04 PM
My Brother and SIL had this problem.
My brother has the balanced translocation but his sperm are unbalanced. Wikipedia has the best articles about that side of things. Basically the person has a balanced translocation and they are a surviving person, but the reproduction side makes them infertile, basically.
I think they may have conceived naturally, one time? Then they had numerous rounds of IVF, before SIL requested further testing for both of them, which at the time, everyone was advising her was unnecessary. Poor SIL had loads of miscarriages before or around 6 weeks, through some of these.
I think there was some little prob with SIL eggs, but it was my brother with the main prob as above.
Then they did quite a few PGD rounds, which is kind of like the technology used in the movie Gattaca, and the embryos got sent to Melbourne for screening.
Then they decided to pursue adoption, but then the country's waiting list which they'd just got onto, closed.
They then decided to go back to IVF this year, and using donor sperm.
Well, I will be an Auntie in January!! She is 32 weeks.
So unfortunately, imho, maybe your friend could look at the donor egg side of things, to somehow get on the waiting list for that, before doing PGD.
However I'm sure someone else here has more experience with it all.
Posted 02 December 2010 - 09:10 PM
We didn't end up having this thankfully, but were tested after our 2nd or 3rd miscarriage. Basically instead of having 2 sets of chronological chromosomes. In this case one or several are mixed up but still have 2 complete sets, so everything works normally. ie i set has 2 x #8 but no #5 the other set has 2 x #5 but no #8.
The implication for pregnancy is that each parent contributes a set of chromosomes. So if the one with defective (for want of a better word) chromosomes puts across the first set the baby would have 3 x #8 and 1 x #5. Therefore incompatible with life (gee I hate that term) and would miscarry.
We went through recurrent miscarriages all with major chromosomal mixups.
I believe IVF with genetic testing may be an option, but I could be wrong, it has been a while since I looked into it after the possibility was ruled out
Posted 02 December 2010 - 09:14 PM
Thanks to those who have replied so far. Please keep the replies coming. I have sent my friend a link to this thread. It is nice to see there is hope out there and all is not lost.
Posted 03 December 2010 - 10:31 AM
Just looked it up in my old genetics textbook. If a parent has a balanced translocation there is a 1 in 6 chance that the conceived fetus will be genetically normal, a 1 in 6 chance that the fetus will carry a balanced translocation (like mum) and 50% chance of abnormal genetic combinations that are unviable (depending on the translocation may be a 1 in 6 chance of live birth with genetic abnormality eg Down syndrome)
Posted 03 December 2010 - 10:44 AM
I have no information to contribute but I just want to say good luck to your friend I hope that everything works out for her and hope to hear good news on her in the near future.
Posted 22 November 2012 - 04:11 AM
Hi, I am 35 and have a balanced translocation 13:15 we were successful after our first attempt at IVF ICSI. Our son is also a balanced translcation like me. I am currently 3.5 months pregnant (fell naturally) and second baby is also a balanced translocation like me. Good luck and stay positive it can happen!
Posted 22 November 2012 - 04:32 AM
My friend has a balanced translocation. She has 2 children.
The oldest has an unbalanced translocation and major issues. She has a moderate/severe intellectual disability and quite a few physical issues including low muscle tone, facial features, hearing loss, short stature etc.
Her younger son has a balanced translocation and no issues whatsover.
She had no issues getting pregnant.
Her sister has had recurrent miscarriages but has had 2 healthy children. I don't think she has been genetically tested.
The child with a disability was part of a research thesis so a lot of time was spent finding the genetic issue and where it came from.
Posted 26 November 2012 - 05:12 AM
Please tell your friend to be careful and seek advice - yes you can conceive naturally with a balanced translocation but you have a larger risk for having a child with chromosome deletions and big issues. It would be wise to inform yourself about these risks. I'm sorry to mention this.
Simply put, each chromosom has 2 arms and these arms can be swapped (translocate) between chromosomes. When someone with a translocation has children, they can pass the translocation onto their child, or the tranlsocation can result in extra or missing genetic material on one or more of the chromosome arms. These are probably the fetuses with chromosomal problems that are misscarried. Someone with a translocation can have some medical issues themselves, duplications also results in some issues and deletions generally alot more.
My DD has a significant chromosome deletion and she's one of the lucky ones whos mostly ok (short statured, some blood problems at birth), but I read every day in a facebook group for children with unusual chromosome deletions - nearly all of these children have global development delays and a range of health issues. DD's case is actually spontaneous (neither DH nor I have any unusual chromosomes), but many of the cases I know of come from parents with translocaitons.
- this is a non-profit foundation for people with rare chromosome diagnoses . There is lots of excellent information about unusual chromosome issues. They might be able to help you more with actual numbers regarding what the risks are and put you in contact with people with similar diagnoses. I really hope things work out for you..
"The effects of rare chromosomal disorders can be very varied. The vast majority of carriers of balanced rearrangements will have no symptoms but might have problems in reproduction. "
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
Get your free ticket to the Sydney Essential Baby & Toddler Show for September 25-27 - register online now.
To celebrate the release of Love Child Season 2 on DVD from July 9, Essential Baby and Universal Sony Pictures Home Entertainment are giving away Love Child Season 1 & 2 on DVD to 13 lucky winners.
I look back at my pre-baby self and laugh at how ridiculously easy I actually had it. I remember complaining about how tired I was and how little time I had.
Ideas for storing your child's artworks have moved on from sticking them to the fridge door before guiltily dumping them in the bin.
Waleed Aly takes apart the immigration law that's designed to "protect politicians"
In August 2013 star basketball Abby Bishop was 24-years-old and in the prime of her sporting career.
No one warned me that when I gave birth there would be an additional side order of guilt.
Check out these creative upcycling ideas that transform regular Ikea items into something special for your little ones.
For three days, a three-year-old boy had been saying there was "a man with a light" outside his window at night.
The thought of going to the toilet after giving birth is often feared, but there are ways to make it less painful.
An anonymous woman is taking an extreme moral and ethical stand by seeking $1 million in donations to prevent her going ahead with a planned abortion.
"I kind of think about, 'What did I do beforehand? What kept me so busy back then?' Because now I'm really busy."
In playgrounds across Australia, you can hear parents lamenting, "When we have our next baby I swear I won't be doing THAT again".
Desperate, out of petrol and low on food, a new mother lit a fire in the hope of attracting attention.
The story was chilling and heartbreaking: a three-year-old boy was found dead in a Southern Maryland park, his mother pushing him on the swing.
Feeling fatigued? Uh-huh, thought as much. Join the queue.
For many new dads, their own child is the first baby they have ever held. So one dad has posted an instructive YouTube video titled "How to Hold a Baby".
She may be only eight months old, but Egypt has already amassed more than 100,000 fans and received a letter from royalty - Hollywood royalty that is.
Tongue and lip tie can lead to many problems for babies - and their parents. Here are the signs of tongue tie and how it's treated.
My daughter may be small, but it's my job as her parent to refocus back where it belongs - on who she is as a person
The government has issued a health warning after a rise in allergic skin reactions has been linked to a preservative found in some wet wipes.
Ultrasounds give you a look at your growing baby ... and sometimes what appears to their womb-buddy, or your bub in an amusing position.
A picture of Ryan Reynolds always gets the girls talking, and a recently shared photo has done exactly that - but this time, it's for all the wrong reasons.
Thinking her baby just had an unusually shaped head, a mother was shocked to discover it was instead linked to a dangerous condition.
Transparency, accountability and responsibilityare essential measures to protect IVF vulnerable patients.
The happily ever after Nicola Milan had imagined wasn't to be – and she blames her mother-in-law.
It's been a whole year since sleeping in until 10am. A whole year since having a peaceful shower.
Over a 10-year period, 83 children died from domestic violence abuse in NSW, with three quarters of the victims aged five years or under, the NSW Ombudsman has revealed.
From the moment that I fell pregnant with my son, I realised just how much my life had already started to change.
"I was terrified I would always be this way. The pill needs to come with a much higher warning."
Unfortunately, the belief that sex should always be spontaneous is a myth. It just isn't.
When it comes to newborn photoshoots, it is all about the timing.
Dr Katie Heathershaw answers questions about jumping, toe walking, riding a bike and being pigeon toed.
Having lost their firstborn at one day old, the Carrolls were overjoyed to welcome their daughter Isobel into the world a year later.
One American father has taken multitasking to a new level at a Cubs-Dodgers baseball game at Wrigley Field.
Choosing a name for your little bundle of joy is always a major decision. It can be something traditional, trendy, creative … or inspired by the menu of your favourite chain restaurant.
This day marks a significant day. Today marks 10 years since I lost my son Kai.
My toddler has started hitting when he gets frustrated, is feeling ignored, or just thinks it might be fun.
From 'morning sickness' to 'the terrible twos', there are many parenting terms that are misleading.
While most nannies take pride in their work, there can be some who have a hidden side.
Beware: skinny jeans might be bad for your health.
A number of women having caesarean deliveries are now taking steps to give their baby a better 'microbiome' start in life.
Jimmy Fallon, host of NBC's The Tonight Show, recently wrote a children's book about every father's secret wish for their baby's first word to be "dada" - not "mama".
Looking for some baby name inspiration for a bub born during the colder months? Here are 28 options from around the world to consider.
Get your free ticket to the Sydney Essential Baby & Toddler Show for September 25-27 - register online now.