Jump to content

Balanced Translocation
Successful Conception (either naturally or assisted) is it possible??


  • Please log in to reply
10 replies to this topic

#1 WarriorWoman

Posted 02 December 2010 - 08:54 PM

Hi,

I am asking on behalf of a friend who has just found out she has a Balanced Translocation and who has been TTC for a while now. Is there anyone in EB land who has this condition or knows of someone with this condition who has had success conceiving?

I am just about to go and do a bit of online research as I am not too sure what it actually is, but she is looking for some info and I thought that this would be a good place to start. I have advised that she sign up herself, but I also hope to be able to offer her some immediate support and this is where you all come in.

I may have posted this in the wrong section, if so, sorry. I would appreciate any info from anyone.

#2 sebela

Posted 02 December 2010 - 08:58 PM

Julia has three kids now - but had a LONG battle with her DHs balanced translocation. Read the archives of her blog:

http://julia.typepad.com/julia/

#3 Feral_RosieC

Posted 02 December 2010 - 09:03 PM

Hi .

I have a balanced translocation.  Didn't find out until after I had conceived my son (first attempt) and then had 4 miscarriages before testing.  After testing I went on to have another 5 miscarriages before using IVF and PGD to conceive our DD.

If she is wanting some info, there is a PGD thread in the AC Buddy Groups section. It had been quiet for a while but there is some activity in there again.

I wish your friend well.

Edited by rosiec, 02 December 2010 - 09:12 PM.


#4 emc002

Posted 02 December 2010 - 09:04 PM

My Brother and SIL had this problem.

My brother has the balanced translocation but his sperm are unbalanced.  Wikipedia has the best articles about that side of things.  Basically the person has a balanced translocation and they are a surviving person, but the reproduction side makes them infertile, basically.

I think they may have conceived naturally, one time?  Then they had numerous rounds of IVF, before SIL requested further testing for both of them, which at the time, everyone was advising her was unnecessary.  Poor SIL had loads of miscarriages before or around 6 weeks, through some of these.

I think there was some little prob with SIL eggs, but it was my brother with the main prob as above.

Then they did quite a few PGD rounds, which is kind of like the technology used in the movie Gattaca, and the embryos got sent to Melbourne for screening.

Then they decided to pursue adoption, but then the country's waiting list which they'd just got onto, closed.

They then decided to go back to IVF this year, and using donor sperm.

Well, I will be an Auntie in January!!  She is 32 weeks.

So unfortunately, imho, maybe your friend could look at the donor egg side of things, to somehow get on the waiting list for that, before doing PGD.

However I'm sure someone else here has more experience with it all.

#5 niksia

Posted 02 December 2010 - 09:10 PM

We didn't end up having this thankfully, but were tested after our 2nd or 3rd miscarriage. Basically instead of having 2 sets of chronological chromosomes. In this case one or several are mixed up but still have 2 complete sets, so everything works normally. ie i set has 2 x #8 but no #5 the other set has 2 x #5 but no #8.

The implication for pregnancy is that each parent contributes a set of chromosomes. So if the one with defective (for want of a better word) chromosomes puts across the first set the baby would have 3 x #8  and 1 x #5. Therefore incompatible with life (gee I hate that term) and would miscarry.

We went through recurrent miscarriages all with major chromosomal mixups.

I believe IVF with genetic testing may be an option, but I could be wrong, it has been a while since I looked into it after the possibility was ruled out

#6 WarriorWoman

Posted 02 December 2010 - 09:14 PM

Thanks to those who have replied so far. Please keep the replies coming. I have sent my friend a link to this thread. It is nice to see there is hope out there and all is not lost.

#7 Angelina Ballerina

Posted 03 December 2010 - 10:31 AM

Just looked it up in my old genetics textbook. If a parent has a balanced translocation there is a 1 in 6 chance that the conceived fetus will be genetically normal, a 1 in 6 chance that the fetus will carry a balanced translocation (like mum) and 50% chance of abnormal genetic combinations that are unviable (depending on the translocation may be a 1 in 6 chance of live birth with genetic abnormality eg Down syndrome)

#8 AnZ

Posted 03 December 2010 - 10:44 AM

I have no information to contribute but I just want to say good luck to your friend I hope that everything works out for her and hope to hear good news on her in the near future.

#9 Kylie : )

Posted 22 November 2012 - 04:11 AM

Hi, I am 35 and have a balanced translocation 13:15 we were successful after our first attempt at IVF ICSI. Our son is also a balanced translcation like me. I am currently 3.5 months pregnant (fell naturally) and second baby is also a balanced translocation like me. Good luck and stay positive it can happen!  original.gif

#10 iwanttosleepin

Posted 22 November 2012 - 04:32 AM

My friend has a balanced translocation.  She has 2 children.

The oldest has an unbalanced translocation and major issues.  She has a moderate/severe intellectual disability and quite a few physical issues including low muscle tone, facial features, hearing loss, short stature etc.

Her younger son has a balanced translocation and no issues whatsover.

She had no issues getting pregnant.

Her sister has had recurrent miscarriages but has had 2 healthy children.  I don't think she has been genetically tested.

The child with a disability was part of a research thesis so a lot of time was spent finding the genetic issue and where it came from.

#11 c_shell

Posted 26 November 2012 - 05:12 AM

Please tell your friend to be careful and seek advice - yes you can conceive naturally with a balanced translocation but you have a larger risk for having a child with chromosome deletions and big issues. It would be wise to inform yourself about these risks.  I'm sorry to mention this.
Simply put, each chromosom has 2 arms and these arms can be swapped (translocate) between chromosomes. When someone with a translocation has children, they can pass the translocation onto their child, or the tranlsocation can result in extra or missing genetic material on one or more of the chromosome arms. These are probably the fetuses with chromosomal problems that are misscarried. Someone with a translocation can have some medical issues themselves, duplications also results in some issues and deletions generally alot more.

My DD has a significant chromosome deletion and she's one of the lucky ones whos mostly ok (short statured, some blood problems at birth), but I read every day in a facebook group for children with unusual chromosome deletions - nearly all of these children have global development delays and a range of health issues. DD's case is actually spontaneous (neither DH nor I have any unusual chromosomes), but many of the cases I know of come from parents with translocaitons.  

Try www.rarechromo.org  - this is a non-profit foundation for people with rare chromosome diagnoses . There is lots of excellent information about unusual chromosome issues. They might be able to help you more with actual numbers regarding what the risks are and put you in contact with people with similar diagnoses. I really hope things work out for you..  

"The effects of rare chromosomal disorders can be very varied. The vast majority of carriers of balanced rearrangements will have no symptoms but might have problems in reproduction.  "


1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users

 

RPA hospital contacting mums after discovering vaccine storage fault

Sydney's Royal Prince Alfred Hospital (RPA) is trying to contact women who had babies at the facility after discovering a fault in a refrigerator containing vaccines.

'Nutella' not a baby name, French court says

A French court has blocked parents from naming their baby girl after the hazelnut spread Nutella, arguing it would make her the target of mockery.

Why I'm never calling myself 'just a mum' again

I’ve grown three human beings. I feed them, dress them, teach them, care for them and love them 24 hours a day. Yet for eight years, when I meet new people and they’ve asked me what I do, I tell them: “I’m just a mum”.

Rosie Batty named 2015 Australian of the Year

One year ago, Rosie Batty could not have imagined she'd be where she is. Tonight the grieving mum who put domestic violence on the national agenda was named Australian of the Year.

Five reasons to hug more

Hugging – some of us thrive on it, even depend on it – and then there are those who don't care for it really. So, are they missing out?

Help - my three-year-old has started throwing tantrums

My daughter never went through the "terrible twos" but began throwing wild tantrums shortly after her third birthday.

That's commitment

First peek at Sonia Kruger's daughter Maggie

"She smells so good, I could eat her," Kruger tells co-host David Campbell.

Mum assists in own caesarean surgery

A mum who partly delivered her own twins during a caesarean has encouraged other women to take control of their birthing experience.

How to handle common childhood regressions

Regression can be a natural and common part of development prompted by a variety of factors, but that doesn't make it less frustrating.

Disgruntled dad's pram ad goes viral

When buying a second hand pram, there are lots of things to take into consideration. 

Man discovers he's a dad after finding 55-year-old letter

Discovering you are about to father a baby is startling enough - never mind finding out you have a 61-year-old son.

15 thoughts mums have during a tantrum

Ranging from mild to feral and triggered by events both minor and major, tantrums certainly keep life interesting.

Natural pain relief in the early stages of labour

While managing labour pains on your own can be daunting, there are a number of natural pain relief options to help you cope until you are admitted to hospital.

Forgotten Baby Syndrome claims the life of toddler

One baby dies every eight days in the back of a car in the US, victims of 'forgotten baby syndrome'.

For a brief time, I was touched by an angel

For a brief time, I was touched by an angel. You stole my heart, and changed me into the women I am today.

Chrissie Swan has reached her "sex quota"

Chrissie Swan says she and her partner have sex once a year due to her fear of falling pregnant.

Chinese woman gives birth to quintuplets

After six years of trying for a baby, a couple’s dreams have come true many times over after the mum gave birth to quintuplets this week.

Five-year-old shoots nine-month-old brother dead

A nine-month-old baby boy died on Monday after he was shot in the head by his five-year-old brother in their grandfather's home.

'Is that baby yours?'

She is my daughter. I gave birth to her. I nurse her. But she doesn't have any of my genes.

Episiotomy in childbirth: not just 'a little snip'

Episiotomies have a place in maternity care – and can occasionally save lives – but should not be performed routinely.

Win an Octonauts prize pack

To celebrate the launch of Octonauts Live! Operation Reef Shield, a spectacular underwater adventure live on stage, we are giving away an amazing Octonauts prize pack to one lucky fan.

Download now: Essential Kids Activity Finder app

Got bored kids? Quickly find the best activities for kids wherever you are in Australia with the Essential Kids app.

 
Advertisement
 
Advertisement
 
 
 

What's hot on EB

Stars help save choking babies

It's an important lesson to learn, but one that busy new mums and dads might overlook until it's too late.

New Girl star Zooey Deschanel pregnant

Actress Zooey Deschanel is expecting her first child with her producer boyfriend Jacob Pechenik.

16 times 'dad reflexes' saved the day

Of course, in some cases they may be the ones who actually got their child into a precarious position in the first place, but we'll ignore that for now.

Couple's 'non-traditional' pregnancy announcement goes viral

Knowing you are not the father of your pregnant wife's baby would usually indicate a rocky relationship ahead for traditional parents.

The trials and tribulations of identical triplet newborns

Pip Donnelly is still playing spot the difference with her newborn identical triplets, Isabelle, Georgina and Frankie.

Win an Octonauts prize pack

To celebrate the launch of Octonauts Live! Operation Reef Shield, a spectacular underwater adventure live on stage, we are giving away an amazing Octonauts prize pack to one lucky fan.

Earthquake baby thriving five years on

Jenny Alexis is lucky to be alive after spending four days buried in the rubble of the 2010 Haitian earthquake, but now she's a thriving five year old.

Please don't say I'm lucky because I was adopted

On the one hand I was having a regular life with friends and sports and sleepovers and school. But I was also always wondering: Did my mother love me? What was wrong with me?

An open letter to non-parents who offer advice on child-rearing

Kitty, when you’re the parent of my child you’re welcome to wade in with an opinion – but until then, I’d prefer you to have a supportive ear and a glass of wine ready.

Couple arrested over baby gun video

A US couple faces charges after investigators say they found mobile phone videos showing the woman's 12-month-old daughter putting a handgun in her mouth.

NSW Health dumps 10-year limit on frozen embryos

A 10-year time limit on storing frozen embryos that were created with donor sperm has been dropped by the NSW government.

How my happy-go-lucky husband became a monster

Sharan Nicholson-Rogers watched her husband change from a happy-go-lucky police officer into an unpredictable man prone to violent and emotional outbursts.

Dads-to-be experience hormonal changes, too

Dads-to-be experience hormonal changes in line with their pregnant partners, a new study shows.

'They were just doing their job': mum of toddler killed in police chase gone wrong

"They were just doing their job. I feel so sorry for them. It is all just too sad."

Miscarriages to be formally recognised by NSW government

Women who miscarry will be able to obtain an optional "recognition of loss" certificate as a formal recognition of their often heartbreaking loss.

Cafe cubby house 'too noisy' for neighbours

Teenage parties, domestic disputes, or raucous late night pubs are the things that usually come to mind when you think neighbourhood noise complaints.

Dad films baby playing with snake

Most parents would not consider a snake an appropriate playmate for their baby, but a US dad who filmed his daughter playing with a python has defended himself against criticism.

Clever breastfeeding products

Check out this range of products designed to help make your breastfeeding journey more enjoyable, manageable and convenient.

 

Back to School Offer

Findababysitter.com.au

We've got you covered for this school year. Use www.findababysitter.com.au to meet local nannies now.

 
Advertisement
 
 
Essential Baby and Essential Kids is the place to find parenting information and parenting support relating to conception, pregnancy, birth, babies, toddlers, kids, maternity, family budgeting, family travel, nutrition and wellbeing, family entertainment, kids entertainment, tips for the family home, child-friendly recipes and parenting. Try our pregnancy due date calculator to determine your due date, or our ovulation calculator to predict ovulation and your fertile period. Our pregnancy week by week guide shows your baby's stages of development. Access our very active mum's discussion groups in the Essential Baby forums or the Essential Kids forums to talk to mums about conception, pregnancy, birth, babies, toddlers, kids and parenting lifestyle. Essential Baby also offers a baby names database of more than 22,000 baby names, popular baby names, boys' names, girls' names and baby names advice in our baby names forum. Essential Kids features a range of free printable worksheets for kids from preschool years through to primary school years. For the latest baby clothes, maternity clothes, maternity accessories, toddler products, kids toys and kids clothing, breastfeeding and other parenting resources, check out Essential Baby and Essential Kids.