Jump to content

Balanced Translocation
Successful Conception (either naturally or assisted) is it possible??


  • Please log in to reply
10 replies to this topic

#1 WarriorWoman

Posted 02 December 2010 - 08:54 PM

Hi,

I am asking on behalf of a friend who has just found out she has a Balanced Translocation and who has been TTC for a while now. Is there anyone in EB land who has this condition or knows of someone with this condition who has had success conceiving?

I am just about to go and do a bit of online research as I am not too sure what it actually is, but she is looking for some info and I thought that this would be a good place to start. I have advised that she sign up herself, but I also hope to be able to offer her some immediate support and this is where you all come in.

I may have posted this in the wrong section, if so, sorry. I would appreciate any info from anyone.

#2 sebela

Posted 02 December 2010 - 08:58 PM

Julia has three kids now - but had a LONG battle with her DHs balanced translocation. Read the archives of her blog:

http://julia.typepad.com/julia/

#3 Feral_RosieC

Posted 02 December 2010 - 09:03 PM

Hi .

I have a balanced translocation.  Didn't find out until after I had conceived my son (first attempt) and then had 4 miscarriages before testing.  After testing I went on to have another 5 miscarriages before using IVF and PGD to conceive our DD.

If she is wanting some info, there is a PGD thread in the AC Buddy Groups section. It had been quiet for a while but there is some activity in there again.

I wish your friend well.

Edited by rosiec, 02 December 2010 - 09:12 PM.


#4 emc002

Posted 02 December 2010 - 09:04 PM

My Brother and SIL had this problem.

My brother has the balanced translocation but his sperm are unbalanced.  Wikipedia has the best articles about that side of things.  Basically the person has a balanced translocation and they are a surviving person, but the reproduction side makes them infertile, basically.

I think they may have conceived naturally, one time?  Then they had numerous rounds of IVF, before SIL requested further testing for both of them, which at the time, everyone was advising her was unnecessary.  Poor SIL had loads of miscarriages before or around 6 weeks, through some of these.

I think there was some little prob with SIL eggs, but it was my brother with the main prob as above.

Then they did quite a few PGD rounds, which is kind of like the technology used in the movie Gattaca, and the embryos got sent to Melbourne for screening.

Then they decided to pursue adoption, but then the country's waiting list which they'd just got onto, closed.

They then decided to go back to IVF this year, and using donor sperm.

Well, I will be an Auntie in January!!  She is 32 weeks.

So unfortunately, imho, maybe your friend could look at the donor egg side of things, to somehow get on the waiting list for that, before doing PGD.

However I'm sure someone else here has more experience with it all.

#5 niksia

Posted 02 December 2010 - 09:10 PM

We didn't end up having this thankfully, but were tested after our 2nd or 3rd miscarriage. Basically instead of having 2 sets of chronological chromosomes. In this case one or several are mixed up but still have 2 complete sets, so everything works normally. ie i set has 2 x #8 but no #5 the other set has 2 x #5 but no #8.

The implication for pregnancy is that each parent contributes a set of chromosomes. So if the one with defective (for want of a better word) chromosomes puts across the first set the baby would have 3 x #8  and 1 x #5. Therefore incompatible with life (gee I hate that term) and would miscarry.

We went through recurrent miscarriages all with major chromosomal mixups.

I believe IVF with genetic testing may be an option, but I could be wrong, it has been a while since I looked into it after the possibility was ruled out

#6 WarriorWoman

Posted 02 December 2010 - 09:14 PM

Thanks to those who have replied so far. Please keep the replies coming. I have sent my friend a link to this thread. It is nice to see there is hope out there and all is not lost.

#7 Angelina Ballerina

Posted 03 December 2010 - 10:31 AM

Just looked it up in my old genetics textbook. If a parent has a balanced translocation there is a 1 in 6 chance that the conceived fetus will be genetically normal, a 1 in 6 chance that the fetus will carry a balanced translocation (like mum) and 50% chance of abnormal genetic combinations that are unviable (depending on the translocation may be a 1 in 6 chance of live birth with genetic abnormality eg Down syndrome)

#8 AnZ

Posted 03 December 2010 - 10:44 AM

I have no information to contribute but I just want to say good luck to your friend I hope that everything works out for her and hope to hear good news on her in the near future.

#9 Kylie : )

Posted 22 November 2012 - 04:11 AM

Hi, I am 35 and have a balanced translocation 13:15 we were successful after our first attempt at IVF ICSI. Our son is also a balanced translcation like me. I am currently 3.5 months pregnant (fell naturally) and second baby is also a balanced translocation like me. Good luck and stay positive it can happen!  original.gif

#10 iwanttosleepin

Posted 22 November 2012 - 04:32 AM

My friend has a balanced translocation.  She has 2 children.

The oldest has an unbalanced translocation and major issues.  She has a moderate/severe intellectual disability and quite a few physical issues including low muscle tone, facial features, hearing loss, short stature etc.

Her younger son has a balanced translocation and no issues whatsover.

She had no issues getting pregnant.

Her sister has had recurrent miscarriages but has had 2 healthy children.  I don't think she has been genetically tested.

The child with a disability was part of a research thesis so a lot of time was spent finding the genetic issue and where it came from.

#11 c_shell

Posted 26 November 2012 - 05:12 AM

Please tell your friend to be careful and seek advice - yes you can conceive naturally with a balanced translocation but you have a larger risk for having a child with chromosome deletions and big issues. It would be wise to inform yourself about these risks.  I'm sorry to mention this.
Simply put, each chromosom has 2 arms and these arms can be swapped (translocate) between chromosomes. When someone with a translocation has children, they can pass the translocation onto their child, or the tranlsocation can result in extra or missing genetic material on one or more of the chromosome arms. These are probably the fetuses with chromosomal problems that are misscarried. Someone with a translocation can have some medical issues themselves, duplications also results in some issues and deletions generally alot more.

My DD has a significant chromosome deletion and she's one of the lucky ones whos mostly ok (short statured, some blood problems at birth), but I read every day in a facebook group for children with unusual chromosome deletions - nearly all of these children have global development delays and a range of health issues. DD's case is actually spontaneous (neither DH nor I have any unusual chromosomes), but many of the cases I know of come from parents with translocaitons.  

Try www.rarechromo.org  - this is a non-profit foundation for people with rare chromosome diagnoses . There is lots of excellent information about unusual chromosome issues. They might be able to help you more with actual numbers regarding what the risks are and put you in contact with people with similar diagnoses. I really hope things work out for you..  

"The effects of rare chromosomal disorders can be very varied. The vast majority of carriers of balanced rearrangements will have no symptoms but might have problems in reproduction.  "


1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users

 

Wondersuit heaven: Bonds & Disney launch exclusive collection

Bonds and Disney fans with babies to buy for will be celebrating this news. Bonds and Disney have just released collaboration Wondersuits.

Town welcomes first baby in 28 years

Since the 1980s, the Italian town of Ostana had not seen the birth of a single baby.

Great-great-grandma delivers great grandchild in her own home

''I've delivered calves, lambs, dogs and cats, but nothing like this.'' This 'Super Gran' calmly peeled the amniotic sac over her great-grandson's head before discovering the umbilical cord was wrapped around his neck ... twice.

How to start teaching your kids road safety

It's something that can be taught as early as possible and reinforced as they get older and more mobile - even from toddlerhood.

Just announced: Bugaboo Cameleon³ Classic+ Collection update

Meet the brand new understated chic model from Bugaboo.

The emotional moment a mum hears her late son's heartbeat

It's been two and a half years since Heather Clark's seven-month-old son Lukas passed away.

Nine reasons why you have 'brain fog'

One minute your productivity is skyrocketing and the next you're sitting there trying to focus – just like that you draw blank, your brain, mush.

I had a caesarean and it was beautiful

Guess what? Despite not pushing him out, I cried, and my heart skipped, and I felt the rush of love and pride when I saw him for the first time.

Microcephaly still a mysterious condition around the world

For parents, having a child with microcephaly can mean a life of uncertainty.

7 baby firsts you won't see on milestone charts

Here are a few 'other' baby firsts you may not have been expecting, but you'll want to be ready for.

Why it's important to vaccinate on time

My son was born on the 1 July 2014. It's a fabulous birthday, don't you think? Not only does the first of July ring in a new financial year, but it also means we've hit the year's half way mark.

Naturopath treatment allegedly left baby "days from death"

A naturopath whose treatment of a baby boy allegedly led to the infant being severely ill has pleaded not guilty to charges against her. 

Andy Murray's emotional speech to pregnant wife after Australian Open

A teary-eyed Andy Murray promised pregnant wife Kim he'd be on the next plane home after his turbulent two weeks at the Australian Open came to an end.

This toddler and his duck BFF will melt your heart

A small boy in the US has struck up a quacking good friendship with an unlikely companion ... his pet duck. 

Great news for coffee drinkers - caffeine is good for your heart

Researchers have found that, contrary to prior belief, caffeine does not cause health-threatening heart palpitations.

I always wanted children - but I've found other ways to be maternal

I've always been one of the most maternal women I know.

When only one parent wants to know the gender

For some couples you either both want to know the gender of your unborn baby, or you don't. For others, it's not that simple.

'No jab no play' could hurt disadvantaged children, experts fear

Tough new "no jab no play" laws could hurt children who have not been immunised due to family dysfunction, poverty, or poor access to medical support, experts warn.

Zika virus: Airlines offer refunds to pregnant women

Airlines and cruise companies across the world are offering refunds or travel credits to pregnant women who are scheduled to visit countries struck by the devastating Zika virus.

#meditateonthis: Mums fight back against PND ignorance

Not all women will require medication, but many will. And there isn't and shouldn't be any shame in that.

 
Advertisement
 
Advertisement
 
 
 

What's hot on EB

Penny Wong

'The most hurtful argument in the marriage equality debate'

Labor frontbencher Penny Wong is used to to hearing arguments against same-sex marriage. But for Australia's most prominent gay politician, one hurts more than others.

Does exercise have to be fun to work?

Some things in life are inherently served with a big scoop of fun: balloons, bubbles, cupcakes to name but a few, but exercise?

Hair dye gives woman second-degree burns

She wanted a fresh colour for 2016, but instead she got chemical burns.

Kelly Slater saves mum and toddler from 'freak wave'

A Perth family has thanked US surfing "legend" Kelly Slater after the star saved a mother and a young toddler from "a freak wave" in Hawaii.

Apple recalls millions of power adapters

Tech giant instigates massive international recall of power point adapters due to risk of electric shock.

Toddler's adorable alphabet goes viral

It's impossible not to share this little boy's excitement  about the alphabet.

Tot's nighttime waking saves family's life

Like all tired parents, Monique and Kyle Ruppel were looking forward to the day their 15-month-old daughter Celia would start sleeping through the night. 

Australian mum gives birth to quintuplets

An Australian mum who has shared the ups and downs of carrying quintuplets has welcomed her five babies into the world.

Dad of four girls faints at gender reveal for fifth baby

It was all too much excitement for this dad.

The simple way you can help your baby's language development

The way parents respond to their child's babbling can shape how their infants communicate.

Zika virus is 'spreading explosively': WHO

The World Health Organization announced that it will convene an emergency meeting about Zika.

National database recommended for child protection cases

Baby Ebony was repeatedly failed by the agencies tasked with her protection before her horrific death at the hands of her father, South Australia's deputy coroner says.

Hospitals put babies at risk by ignoring policy on elective caesareans

Thirty-eight weeks or 39? Non-medical factors are pushing women to have elective caesareans earlier than official guidelines - and hospitals are playing along.

Police help deliver baby on busy roadside

Two police officers delivered more than a traffic fine by the side of a busy Melbourne road yesterday.

1D's Louis Tomlinson shares first photo of baby

One Direction's Louis Tomlinson has posted the first picture of his baby boy, Freddie, on social media.

 

FREE TICKET

Free first aid demonstrations daily

Get your free ticket to the Essential Baby & Toddler Show and save $20 - register online now!

 
Advertisement
 
 
Essential Baby and Essential Kids is the place to find parenting information and parenting support relating to conception, pregnancy, birth, babies, toddlers, kids, maternity, family budgeting, family travel, nutrition and wellbeing, family entertainment, kids entertainment, tips for the family home, child-friendly recipes and parenting. Try our pregnancy due date calculator to determine your due date, or our ovulation calculator to predict ovulation and your fertile period. Our pregnancy week by week guide shows your baby's stages of development. Access our very active mum's discussion groups in the Essential Baby forums or the Essential Kids forums to talk to mums about conception, pregnancy, birth, babies, toddlers, kids and parenting lifestyle. Essential Baby also offers a baby names database of more than 22,000 baby names, popular baby names, boys' names, girls' names and baby names advice in our baby names forum. Essential Kids features a range of free printable worksheets for kids from preschool years through to primary school years. For the latest baby clothes, maternity clothes, maternity accessories, toddler products, kids toys and kids clothing, breastfeeding and other parenting resources, check out Essential Baby and Essential Kids.