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Low estrogen levels

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#1 Puddycat

Posted 21 January 2010 - 07:51 AM

Good morning all,

I have just come back from my second scan and I have a few questions.

This is our third cycle.  First cycle we got one totally crap quality egg.  Second cycle was cancelled due to poor response.  And this cycle looks like it is heading the same way.

I’m on Gonal-F 450iu and started jabbing on day one.

Apparently my estrogen levels are way too low.  They were so low (unfortunately I don’t know the exact level) that he didn’t even bother to scan me today.  I had more bloods done today.

I have been stimming for 8 days now.  On day 6 I had a scan, and there was possible 1-2 follies there, but he couldn’t really tell as they were so small and my bowel was a bit too full.

He keeps talking about having to “catch the wave”.  He said we have missed it again this month.  He thought by starting me stimming from CD1 that we might catch it, but he said we haven’t.  I don’t quite understand his analogy.  

I am going back for a scan on Sat morning.  I’m frustrated I didn’t get a scan today, now I have to wait until Sat to find out whats going on.  I am going to call the rooms after lunch to see whats happened to my estrogen levels.  I will ask then what they were two days ago and what they are today.   Hopefully someone here can tell me if they are looking better.

I know its only early days, but I’m really upset.  I was super super positive this cycle (as I haven’t been that positive for the others) and now its been ripped out from under my feet.   I guess the higher you go, the further you have to fall.  And the landing hurts.

I feel so let down by my body.

Thanks for listening.

#2 LittleM

Posted 21 January 2010 - 10:14 AM

oh gee im sorry to hear of your rough trot!! that sounds so frustrating!!! io really hope they can sort it out!!!

it would be good if someone comes in with a similar situation and has a positive outcome!!!!!

good luck and i hope things improve soon!!!!

#3 pundelina

Posted 21 January 2010 - 10:39 AM

oh Puddycat I'm so sorry to hear this. Don't give up hope yet though - some people take longer to stim than others and that can be ok.

He keeps talking about having to “catch the wave”. He said we have missed it again this month. He thought by starting me stimming from CD1 that we might catch it, but he said we haven’t. I don’t quite understand his analogy.

When your doc says he wants to 'catch the wave' he means he wants to hitch your artificial FSH dose onto the naturally occurring rise in the first few days of your cycle - he may even try giving you luteal FSH next time.

I really hope you have a better report after your next scan. I know how awful you must be feeling.

#4 Puddycat

Posted 21 January 2010 - 02:50 PM

Thanks for the replies.

Pudelina - your a gem.  I will print that out and digest it tonight (Im at work at the moment).

I called the FS and was told that my levels have increased, but Im not sure if its by enough.  The nurse said that my levels on Tuesday were 169 (CD6) and they were 254 (CD8) today.  Apparently the FS said they were "sort-of OK" for someone who doesn't produce very many eggs.

Can anyone shed any light on what the E2 levels are meant to be at this stage?  How low are mine?

Thanks heaps.

#5 LittleM

Posted 21 January 2010 - 03:47 PM

hi well at leats u are improving! thats good right?!?!

for me, this epu my e2 was 7000. last tiem it was 2000. i think they like 200 (was it?) about per mature follie?!

aha, found this. u might find it interesting?!!?!

good luck for the rest of this cycle!

#6 Earth-Angel

Posted 21 January 2010 - 05:31 PM

They want to see an E2 level of about 800/mature follicle for it to actually conatin an egg. With my body (i was classed as a poor responder too) my E2 would normally stay low and then jump very dramatically in only a few days so dont loose hope yet.

If E2 is a big problem for you maybe you want to do some research on estrogen priming cycles (done a lot in the USA) and maybe this is an option for you. I have read a lot of your posts and personally I don't get the feeling that your fs is a good match for you imo. I'd give him one or two more cycles then find someone else if it was me. Hopefully you'll have success before then original.gif

#7 JFE

Posted 22 January 2010 - 01:53 PM

Hi Puddycat

Just a quick email today as work is super busy, I hope to email more over the weekend.

Unfortunately I know how you feel, I have low estrogen levels this cycle too and am feeling really let down by my body. It’s got to be my worse cycle so far.

I had a blood test done on CD4 my estrogen levels were 43, I was told not good and my cycle would most possibly be cancelled but to keep up the drugs and come back on CD6. CD6 being today showed my estorgen has raised to 114 so they want me to keep going with drugs and come back Monday for another blood test to decide from there. In my other cycles from memory m last blood test before EPU usually shows estrogen levels at 9000.

If my levels don’t rise much I am going to ask them to either cancel or change my cycle to an IUI. I too was trying to be positive about this cycle also as I have been taking DHEA for 5 months and was hoping it was going to make all the difference.

Thanks Pundelina for the info and graphics …quot; I will have a good look over the weekend

Edited by JFE, 22 January 2010 - 01:54 PM.

#8 Puddycat

Posted 27 January 2010 - 05:18 PM

Well for once its good news!  I appear to have had a last minute rise in my E2 levels.  I'm so excited!

They went from 169 to 254 to 490 (Friday) and then 2407 today.  There are three follies (not very big though - ranging from 10-18mm) on one ovary and five really small (i.e. wont be viable) on the other ovary.  So thats fantastic news.  EPU is Friday.   I know that I cant get my hopes up too high - as those follies are still small and may not contain a mature egg.  But I'm still pretty happy to have made it this far.

The FS is also happy that there has been a response from both ovaries this time.  

Earth Angel - I agree with you.  I am not sure if the FS and I are a good match.  He is meant to be one of the best in the field and all the nurses rave about him (not his personality or his bedside manner - just his ability to get people their BFP.  I really don't know what to do.  I was with another clinic, and I didn't like the FS, so I changed clinics and went to a mainstream one.  Everyone recommended this FS to me.  He is always in the journals and media as he is meant to be so good.   Agghjhh...Its so hard!  I don't know what to do.  I cant keep changing clinics/FS.  How do you know if you are a good "fit" with your FS??  Thanks for the info that its about 800 per mature egg.  That fits in nicely with my numbers from today.

JFE - How are you going?  Have your levels risen?  I cant change to an IUI as we have pretty bad MFI issues.

#9 Puddycat

Posted 30 January 2010 - 12:25 PM

I am ecstatic to report we got three eggs yesterday (two good ones and one really dodgy one).  The two good ones fertilised overnight    ddance.gif   but they didn't bother with the third - it wasn't good enough to attempt fertilisation.  Find out early Monday morning if they are behaving themselves nicely and dividing as they should.  Transfer will be late Monday morning.

In regards to the estrogen issues, I am going to change my diet.  I have done a lot of Google research and there are lots of foods out there that can increase estrogen.  Luckily for me they are all vegetables - and I'm a vegetarian.  There are also a lot of foods (also vegetables) that inhibit estrogen, so I will have to remove some of them from my diet (which is a shame, as some of them are my favorites - such as corn and broccoli which we grow in our garden).  Regardless of if this cycle works or not I am going to do the change in diet, as a lot of the other symptoms they list also affect me (I had no idea!).  So maybe this will end up in being a benefit for not only my fertility but also my overall health.

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