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Prog pessaries vs Crinone

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17 replies to this topic

#1 UniKitty

Posted 29 June 2006 - 10:39 PM

I am starting my first medicated FET cycle soon and have been prescibed prog pessaries. Unfortunately *TMI* they irritate my 'whatzit' pretty much straight away and leave me with shocking thrush  blush.gif . So when I was told I need to use them 3 times a day for up to 10 weeks, I just groaned  <_< . Yes, rectal application was suggested but I just can't bring myself to do it!!!

So now I am looking for an altenative. During my last IUI cycle I was on a double dose of Pregnyl injections in the 2ww instead of pessaries, but obviously I don't have that choice this time.

Can anyone tell me about Crinone:

How often do you apply?
How is it applied?
Have you had a reaction of any kind?
How much does it cost?
Anything else you can think of???

Are there any other alternatives ie injections, tablets, skin patches??

Thanks in advance

Edited by Duffa, 29 June 2006 - 10:40 PM.

#2 A32

Posted 29 June 2006 - 11:18 PM

Two words Jodes - paper mache. When you try them you will know what I mean.

Seriously though, I used them for my stim cycle and I inserted them once or twice a day (can't remember it was so long ago - sad). They are not as strong as the progesterone pessaries and not as slimey IMO. They don't leak out like the progesterone pessaries do. I didn't have a reaction but about five days after using them I had the paper mache effect. I was like.... what the hell is that up there?! It seemed to turn into paper.

Not sure how much they are but surely they are not as expensive as the $60 per week progesterone. After 14 weeks of pessaries twice daily over the past 8 months I am completely and utterly over them.

PIO shots (progesterone in oil injections) are not available in Australia anymore I believe. I asked about them too.

Good luck. Let me know how it goes.

#3 Little~Oggy

Posted 30 June 2006 - 07:04 AM

Jodes it won't actually be thrush most likely it would more likely be a reaction to the coconut oil they place on pessaries.
The main thing with crinone it the cost involved. Also taking a latcos bifficlous (sp? sorry) tablet during treatment would help if it does turn out to be thrush.
Personally I found crinone much better!.......Amber would have had to pay a small foruntue on this stuff because nearly all FETS!

#4 AlyV

Posted 30 June 2006 - 07:11 AM

Hi Jodes,

I haven't used the pessaries, but have just finished on the Crinone. I inserted them twice a day and found that I had to wear a panty liner as there was some discharge (love the paper mache comment!). I also experienced external itching but no thrush. Can't think of anything else sorry. I have used the Pregnyl in the past and found that I had terrible cramping with it.

All the best.

#5 jules095

Posted 30 June 2006 - 08:46 AM

Hi Jodes

I never had pessaries, so I can't comment on them.

I had Pregnyl for my 2nd stim cycle & liked it, becuase it was less fuss. The only thing is, it delayed AF by a couple of days, getting my hopes up.

For stim #1 & #3 I used Crinone. So I'll try to answer some of your question.

How often do you apply?

I used it once a day, but I have heard of people using it twice a day.

How is it applied?
It's a cream like substance, in an applicator. You just insert  it, then squeeze the top to release the Crinone.

Have you had a reaction of any kind?
I had cramping & sore (*)(*)s. It also (by the leaflet inside the packet), gives you a feeling of sadness & unworthiness.

How much does it cost?
Not really sure, but it was included in the cycle costs.

Anything else you can think of???
As the girls have said, there is a bit of leakage. I didn't have a problem until about 4 or 5 days after I started to use it. Then it started to come out.

Crinone delays AF for some people, but I got AF right on time (both times sad.gif )


Jules xoxoxo

#6 Nut

Posted 30 June 2006 - 09:14 AM

I have not used crinone but from what I have come across it is more expensive... Other than that I can't offer much info there.

One thing you could try if willing is to use the Pesseries anally rather than vaginally. Many others have done it and claim it to be less messy, more appropriate for day time applications (doesn't leak as much so the rest time is reduced) and won't cause thrush...

#7 sebela

Posted 30 June 2006 - 10:49 AM

I HATED crinone, gave me awful cramps and headaches, much preffered pessaries and found the mess factor to be fairly equal...

#8 AnotherFeral

Posted 30 June 2006 - 01:06 PM

For my last medicated FET, my FS said Crinone was too expensive, even though I had some irritation from the pessaries sad.gif. He didn't think the absorption would be adequate if I used them rectally (I know blood P4 levels can be higher from rectal application of the pessaries, but I guess he meant absorption into the endometrium). FS didn't want me using the injections either, as apparently they can have nasty effects at the injection site & sometimes cause infections.

#9 ellejaye

Posted 30 June 2006 - 02:46 PM

Hey Jodes

I had Crinone for my 2WW, and 'Messaries' as I call them suck!  But I guess we can't get through without them so here's what I recon...

How often do you apply?
I used it once a day, just as I was getting into bed so no problems with leaks during the day.  This was until 5ish days after I started and I got a small amount of discharge (kinda like paper mashe as amber said before) but nothing a small pantie liner didn't fix.

How is it applied?
It's in a tube (like those tampons with the applicator) with a little square at the end that holds the cream.  You insert it all the way up and squeeze the square with the cream a wallah done.

Have you had a reaction of any kind?
I was positive I was pregnant apart from the BFN HPT's.  Sore boobs, mild cramps, emotional, nausous etc but these are normal reactions.

How much does it cost?
No idea coz mine was included in the cycle cost.

Anything else you can think of???
Not really.  They weren't that bad, but hey if you're feeling up to doing the deed do it "BEFORE" you apply LOL
Oh and to follow on from Jules...Crinone did delay AF for me (hence thinking I was P).  I got to 14dpo still no AF (she's usually here by 12dpo for me) and AF didn't arrive until 3 days after I stopped applying them.

HTH original.gif

Edited by ellejaye, 30 June 2006 - 02:48 PM.

#10 misty_3

Posted 30 June 2006 - 04:12 PM

hi there, everyone pretty much sumed up about the crinone, but it is very expensive, im still using it and i finish my last one this saturday, but at my clinic its $150 for a box of 15. and you can not claim it back of medicare, and i use 1 a day for about 10 weeks.
the only thing that i hate is the discharge, with me it mainly comes out when i go to the loo, sorry if tmi, its kinda like a dry cottage cheese or a wet mushed up paper  blush.gif

#11 beccababy

Posted 30 June 2006 - 04:30 PM

I am on my 8th week of progesterone pessaries and I cannot tell you how much I HATE them.

For a start most if it seems to end up in the toilet and I'm sure it's not healthy for our waterways to have all these hormones getting into the foodstream (I bet I'm causing boobs in male fish or something...).

Even when you do 'stick them up your bum' which the nurse so tactifully suggested it still comes out!!

I can't wait to finish them but you have to wean yourself off them as your body gets used to them. From eight weeks the placenta starts making its own progesterone THANK GOD.

I know I should be grateful I still have a reason to take them but gee wiz they are annoying!

#12 shangobunni

Posted 30 June 2006 - 04:39 PM

I hated crinone so i used "messaries" I had to use 4 a day for 14weeks.. but hey ofcourse its worth it either way.

Crinone is equal to 3 pessaries so costs the same as 3 pessaries... at my clinic anyway..

Good luck  smile1.gif


#13 Nut

Posted 30 June 2006 - 04:47 PM

I have just started using them again... Progesterone was really good and I thought I would be fine with out them but it started dropping...

was rather disappointed when I was told to go back on 2 a day...

#14 StillRoz

Posted 30 June 2006 - 04:56 PM

Gees - $150 for 15 crinone seems an extreme price for a clinic to charge.
I ran out of crinone over Christmas/New Year and had to hunt around to get some on Dec 31st! My clinic was closed, the FS was uncontactable and no other doctor seemed to have any idea how to get any. A registrar at RWH managed to track some down for me at a pharmacy in Merrylands, but was unable to get the proper authorisation (from PBS in Tassie I think) to give me some special script (so that PBS would cover some of the cost). I had to pay the full "private" amount for crinone - which was $90 for 15. Clinic should be charging less than this as they obviously have the authority to prescribe it.

Also re. crinone .... it seems with pessaries that people are advised to lie down after use to help it get absorbed. My clinic gave very strict instructions when using crinone to use it at the end of the day, after shower and toilet, and then to walk around for 1 hour. It seems that something about the walking around helps it be absorbed. I didn't get much 'leakage' (just had to remove some 'paper mache' when having a shower blush.gif ) despite taking it daily for 8 wks. My progesterone level was always really high on crinone (~16dpo ... p4=500+).
If I was doing it all again, I would definately go with crinone again.
All the best

#15 beabea

Posted 30 June 2006 - 05:26 PM

Just a thing - I got that itch the first FET cycle with pessaries but it doesn't seem to be happening this time around, for some reason.  More deft at applying/cleaning up after?  Body decided not to react the same way?  Dunno.  But if you decide to stick with them, don't be too afraid...

#16 Little~Oggy

Posted 30 June 2006 - 06:32 PM

I've got to agree with Roz here....I reckon pessaries are way worse for leakage factor than crinone. The crinone sort of sits in place more.......and here's the STMI!

Cotton tips work great at clearing the little lumpies of cottate chesse that start fallling out on their own.

Roz I'm not sure what happens with non-ed cycles using crinone but I know with a ed they give you there first box PBS covered but then from there on in it doesn't get covered because there is somethng in the PBS that states it must be with the womans own egg.


#17 UniKitty

Posted 01 July 2006 - 01:40 AM

Thanks to everyone for the replies!

It seems there are positives and negatives for both systems. I think I am going o ask my F/S about using Crinone because I really want to avoid the irritation and extreme itching caused by the pessaries. I also like the idea of not having to lie down after application because it is not an option at my work for the midday dosage.

I guess if the Crinone is a problem I could always swap back???

Oh and has anyone managed to claim Crinone or Pessaries under pharmaceuticals through their health insurance (especially MBP)?

You know when I first started the whole ART roundabout, I always thought having to inject myself would have to be the worst thing ever. Now I actually find injections the easiest aspect of treatment  wacko.gif ! Syneral sniffing and pessaries are much much harder to deal with and really affect my day to day life.

Does anyone else think the same or am I just weird??

#18 Little~Oggy

Posted 01 July 2006 - 06:21 AM

Jodes I claimed my back through HBA and got like a huge $20 back from about $180. I even tried to see what the laws where in regards to importing it through USA. The main issue there being none of the companies would send it, from memory there is some legal clause about it being okay to bring it in for personal use but none of the US compaines will do it.


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