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Using Human Growth Hormone (Saizen) in IVF cycle?


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#1 MsHopeful18

Posted 30 May 2018 - 08:52 PM

Hi all,

Hoping someone is able to share their experience with using this injection?

My FS has suggested I try it with IVF#3 in the hope of getting better numbers and/or quality. It’s very costly at over $1k and I am on the fence about using it when there doesn’t seem to be a great deal of evidence about it.

He is also wanting me to use Synarel as a trigger instead of Ovidrel so I am quietly freaking out about the fact that this seems to not be used much when someone is already a poor responder like me?

Thanks so much in advance!! I have about 2 weeks to decide before we start.

#2 TimeWillcome

Posted 15 June 2018 - 12:15 AM

I realise you posted this a few weeks ago and got no replies. I’m sorry I can’t be helpful but what did you decide MsHopeful18 about using Saizen? I’m in a similar situation with it being recommended to me by my FS but I’m hesitant due to the cost and to not knowing if it actually helps and how it would help.

Can I ask why your FS recommended it for you? My issues haven’t been confirmed but egg quality certainly isn’t great (it’s awful actually) so contributing to my lack of success so far with IVF.

I’m sorry my response isn’t an answer to your question but I’m keen to hear if you decided to use it and if you did how did it go? Also, cost wise I was told it was over 1k as well. I phoned quite a few pharmacies most said they didn’t stock it and couldn’t order it and only 1 actually gave me a price quote. others said they could order but couldn’t give me a price unless I confirmed the order and would buy.

Keen to hear what you decided and how things are going for you now.

 MsHopeful18, on 30 May 2018 - 08:52 PM, said:

Hi all,

Hoping someone is able to share their experience with using this injection?

My FS has suggested I try it with IVF#3 in the hope of getting better numbers and/or quality. It’s very costly at over $1k and I am on the fence about using it when there doesn’t seem to be a great deal of evidence about it.

He is also wanting me to use Synarel as a trigger instead of Ovidrel so I am quietly freaking out about the fact that this seems to not be used much when someone is already a poor responder like me?

Thanks so much in advance!! I have about 2 weeks to decide before we start.

Edited by TimeWillcome, 15 June 2018 - 12:19 AM.


#3 MsHopeful18

Posted 15 June 2018 - 11:23 AM

I have decided to wait out another cycle before starting our 3rd round as I have only just started taking DHEA. I haven't decided about Saizen yet, I think I will probably end up doing it as this will be our "throw everything at it" third round of IVF.

My FS recommended it because I am a poor responder with only 6 eggs collected out of two cycles, and none grew to blastocyst by day 5. He acknowledged it wasn't a huge amount to base it on but thinks I have quite poor quality eggs as my husband's test all came back really good.

Good luck deciding too and let me know what you decide! Doesn't seem to be widely used here at all.

#4 Wonderstruck

Posted 18 June 2018 - 08:30 PM

I’ve used Synarel as a trigger. My FS did it as we were doing ivf to screen out a genetic disease so we’re pushing for a high number of eggs and they wanted to reduce the risk of OHSS - they didn’t want to do a fresh transfer after the Synarel trigger.

What have you decided? Did the doctor outline why the change might help?

#5 MsHopeful18

Posted 19 June 2018 - 12:55 PM

 Wonderstruck, on 18 June 2018 - 08:30 PM, said:

I’ve used Synarel as a trigger. My FS did it as we were doing ivf to screen out a genetic disease so we’re pushing for a high number of eggs and they wanted to reduce the risk of OHSS - they didn’t want to do a fresh transfer after the Synarel trigger.

What have you decided? Did the doctor outline why the change might help?

My FS did say something about trying Synarel because of the different way it makes the pituitary gland respond but I was so overwhelmed I didn't really make sense of it.

I am a poor responder so no risk of OHSS, he said it does cause the lining to be less receptive so I would need both Crinone and Ovidrel clicks as luteal support.

We've decided to wait another month for DHEA to work and then will try with all the new changes and hope third time is the lucky one!


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