Jump to content

Anyone know much about anti e antibodies and amniotic fluid embolisms?


  • Please log in to reply
3 replies to this topic

#1 *~~Jess~~*

Posted 25 January 2013 - 06:49 PM

After the birth of DD2 I developed an amniotic fluid embolism and also diagnosed with anti e antibodies.

It was discovered that I still have the antibodies when I had bloods done for this pregnancy. I have spoken to my OB and the chance of another embolism occurring is low but I will need to see the high risk clinic because of the antibodies and the risk to my baby because of them.

Has anyone else had an amiotic fluid and not had another one in your next pregnancy?

Also has anyone had anti e antibodies, did your baby have any side effects at birth because of it?

#2 kwiggle

Posted 25 January 2013 - 07:07 PM

Congrats on your pregnancy Jess - I reckon you'll be pretty bored of hospitals and doctors by the end of this one! biggrin.gif
The most likely thing is that your pregnancy will be boring, but they will take lots of blood tests to make sure your antibody levels remain stable, and if they go up will do lots of ultrasounds to check whether your baby is becoming anaemic.  Worst case scenario (and pretty rare) is that your baby would need blood transfusions in utero.  
In terms of the amniotic fluid embolism.... noone will be able to tell you what the risk of recurrence is reliably because it's so rare.  My best guess is that it's unlikely to happen again.  
You're a brave lady - are you coping with the idea of being pregnant again?  I hope you don't have too many scary thoughts.... I don't have any personal experience with those issues, but wanted to reply because I can imagine it's going to be a stressful time for you.  Good luck!

#3 katpaws

Posted 06 March 2013 - 10:31 AM

Hi Jess

I had an AFE 10 years ago but have been diagnosed with secondary infertility so no second baby.  I had decided to go for a CS (elective) if i got pregnant again  - the AFE occured during an attempted vaginal birth.

I understand that the chance of another AFE occuring in subsequent pregnancies is very very low. However, my OB did advise having an CS and avoiding labour with another baby, however my AFE was pretty bad so this may affect medical advice given.

I would recommend that for your next pregnancy you have an OB you have a high level of trust in and in the health professionals supporting you. If you suffer from PTSD you need to advice your medical team, also be aware that flashbacks to the AFE could occur so have a management plan for that. I would advise having someone with you during your labour or CS (whichever way you go) and not being left alone, even for a few minutes, so someone is always monitoring you.

When you book your hospital ask them about their AFE management plan ie do they gave the cogulation products needed on hand? Do they have an intensive care ward in case things go wrong?

AFE is on the suckiest worst things that can happen to you. The fact that it is not predictable and can't be tested for just makes it such a horrible thing.

Best of luck with everything




#4 deejie

Posted 06 March 2013 - 09:01 PM

QUOTE (*~~Jess~~* @ 25/01/2013, 07:49 PM) <{POST_SNAPBACK}>
Also has anyone had anti e antibodies, did your baby have any side effects at birth because of it?


Anti-e (lower case) is a different antibody to Anti-E (uppercase). I'm not sure if you meant the lower case "e" or not, so will cover both.

Anti-E can sometimes be naturally occuring. The naturally occuring Anti-E antibodies are usually low titre and of little clinical concern. Immune Anti-E which were stimulated by previous pregnancy/transfusion are usually associated with mild -> moderate effects in the developing fetus. Severe fetal anaemia from Anti-E antibodies is uncommon.

Anti-e antibodies are very rarely naturally occuring and are usually the result of previous pregnancy/transfusion. They are typically associated with mild -> moderate effects in the developing fetus and like Anti-E, severe fetal anaemia is uncommon.

Your partner will be tested for the E/e antigen. If he is heterozygous (one copy of the gene), your baby will have a 50/50 inheriting it and being at risk. If he is homozygous (two copies of the gene), your baby will definitely carry the E/e antigen and will be at risk.

I'm sure you will be sick of ultrasounds and tests by the time your pregnancy is done!
Most antibodies are still quantitated in the laboratory by a test called the  antibody titre which is performed on a sample of your blood. This gives a rough estimate of the "level" (for lack of a better word) of antibody in your blood. The higher the titre, the higher the level of antibody and (generally speaking) the higher risk involved for your baby. In some pregnancies, the titre remains stable throughout. In other pregnancies, it can go up a little or a lot.

There are ways of typing the baby for the E/e antigen before it is born. It can be done via amniocentesis and extracting fetal DNA from a sample of amniotic fluid. Amnio obviously carries risks. Fetal e/E antigen typing can also be done on a sample of maternal blood from the second trimester. Fetal DNA can be extracted and typed. These tests are usually done when the maternal antibody is one of the "nasty" ones (D, K, c), the titre is very high the baby is considered at high risk. It is rarely done in the case of Anti-E/e. Otherwise, monitoring tests will show whether the baby is affected.

If your titre is high, your OB team will monitor the health and wellbeing of your baby by MCA (middle cerebral artery) ultrasound. They measure the velocity (speed) of the blood in the middle cerebral artery in your baby's brain. If you have lots of antibody crossing the placenta and destroying your babies red blood cells, your baby will be anaemic. Its heart will beat faster to pump a smaller volume of red blood cells around its body and therefore the velocity of the blood increases. The velocity of the blood is a good indicator of how anaemic your baby is and the treatment it needs (further monitoring, early delivery, transfusion still in the womb in very severe cases).

Babies used to be monitored by looking at the bilirubin levels (a red blood cell breakdown product) in the amniotic fluid. This was done by amniocentesis, but this is not done very often these days due to the risks associated with amnio vs the non-invasive MCA ultrasound.

Intra-uterine transfusion in cases of Anti-E/e is rare. Most babies are born closer to term. Rarely (in cases of very high titres) they will require an exchange transfusion soon after birth. This removes the maternal antibody from their system and replaces their own "E" or "e" type red blood cells with cells from a donor which are compatible with the maternal antibody. Most babies born to Mums with Anti-E/e and moderate to high titres will have jaundice and will have treatment under the UV lights (similar to other babies who have jaundice for other reasons).

While it does sound scary, the OBs at the maternal fetal medicine unit that you will be attending really are the experts at handling immunised pregnancies. Don't be afraid to pepper them with a thousand questions. You will be in the best of hands.

edit- to make more sense (I think)

Edited by deejie, 06 March 2013 - 09:04 PM.





1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users

 

Win a Mountain Buggy Swift

To celebrate Essential Baby reaching half a million Facebook fans, we have a Mountain Buggy Swift to giveaway to a lucky fan.

Shopping with kids: breaking the pester-power cycle

You're out shopping with your little one and they're incessantly whining that they want a treat. It's easy to say no ... the first time, at least.

eBay jacket may hold clue to murdered girl's identity

A jacket similar to the one found with the remains of a brutally murdered little girl in South Australia has been identified on eBay.

New mum forced back to work early due to paid parental leave 'technicality'

Shelley Parker had to keep driving buses until the date her baby was due and will have to rush back to work at the end of this week after being denied paid parental leave on a "technicality".

Pregnant Amanda Palmer poses naked for book drive

It has to be the most original way ever of promoting a children's book donation day.

The conception dilemma facing many parents today

Some parents who conceived through a sperm donor will be wary of telling the child, while others prefer to deal with it early on. But recent research suggests it makes little difference either way.

The wedding photo the bridesmaid would rather forget

We've probably all seen a passed-out bridesmaid at one wedding or another, but it usually happens towards the end of the night.

Pregnant TV meteorologist takes on haters

Pregnant TV meteorologist Katie Fehlinger has hit back at haters who called her a "sausage in casing".

Honest words from first-time mums

I didn't want to say anything negative to my pregnant friend, but I wish I'd been more honest.

Adorable baby experiences rain for the first time, couldn't be happier

Harper had seen rain from the comfort of indoors before, but had never had the pleasure of being outside and experiencing it first hand.

What it's really like to start a family in your fifties

Many people suppose that it must be much more tiring to have a baby in middle age, but all the mothers in the playground look exhausted, whatever their age.

'Biggest hypocrite ever': Josh Duggar admits to Ashley Madison account

An American reality TV star has been busted with a cheating website account, according to US media.

Long recovery ahead for girl hit by car weeks after baby brother's death

A little girl is more alert and starting to talk after being hit by a car a week ago, but still faces a long recovery.

How to react when a toddler lies

Q: My almost-3-year-old is starting to figure out that he can lie when asked if he ripped the book, threw the food, hit his brother, etc. Totally normal, I know. How do we respond?

The circular experience of a Centrelink client

A mum-to-be experiences the frustration of dealing with Centrelink, myGov and everything in between.

Kelly Clarkson announces live on stage: 'I'm pregnant!'

Singer Kelly Clarkson has announced she is pregnant with her second child during a concert in Los Angeles.

Hack

How to search the leaked Ashley Madison data

At least three sites are republishing Ashley Madison's user data on the public-facing internet.

Mum dances her way through labour

There are a fair few ways to distract yourself and beat pains while in labour, but it's probably a rare woman who chooses her dance her way through it.

'Rest in peace, my little lion': premmie baby Jacob passes away

Baby Jacob, whose photo of him born at just 27 weeks was deemed 'too graphic' for a fundraising site, has died.

Mum killed three young sons 'to help her daughter', prosecutor says

Niall Pilkington's death last summer apparently raised little alarm in Bellefontaine, Ohio. Tragic accidents happen, after all.

Shorter women have shorter pregnancies: study

When a group of researchers studied nearly 3500 mothers and their babies, they noticed a curious pattern.

Get your FREE Baby & Toddler Show ticket!

Get your free ticket to the Sydney Essential Baby & Toddler Show for September 25-27 - register online now.

 
Advertisement
 
Advertisement
 
 
 

What's hot on EB

The worst 20 minutes of my life

Thirty seconds was all it took to turn a shopping trip into my worst nightmare.

Top baby names for England and Wales in 2014

George has overtaken William in the official rankings of most popular British baby names - and Game of Thrones is still having an impact on parents.

Baseball or baby? Dad's tough choice

What's more important, a baby or a baseball? That's a question this dad seems to struggle with.

Childbirth choices: five star or free?

It's not often you hear the words labour and luxury in the same sentence but for some, a 5-star start to parenthood is exactly what they seek. And with a number of private hospitals now offering packages which include a post-birth stay at a sumptuous first class resort, many mums are choosing to recover in style.

'Where did your boobies go, Mummy?' and other soul-destroying comments from kids

Most women carry a smidge of baby weight after giving birth. If you're lucky enough to have an older child in the house, they can keep you on track with your weight loss goals.

Do you read me, baby?

Is it too soon to be reading to my two-month-old son? If not, what should I read?

Minimising sibling rivalry when you've got a baby

Sibling rivalry is an act of competition, but if your children feel involved and special, this type of jealousy will be minimised.

Will studying on maternity leave take you away from your most important job?

I remember when I was trying to decide if I could combine motherhood and furthering my university education.

Win a Pacapod this Father's Day

To celebrate dads and families, we are giving away a Picos Pack from Pacapod Australia filled with a few extra goodies ENTER NOW

Preschooler hit by car shortly after baby brother's death

A mother has had a frantic race to the hospital after her daughter was hit by a car, just four weeks after her infant son died.

Gay couple and Thai surrogate in custody tug-of-war

A six-month-old baby girl is trapped in the Thai capital in a bitter custody wrangle between her Thai surrogate mother and her biological father.

Couple denied IVF over parenting concerns

A mother of six has been denied access to IVF treatment in order to have another child over concerns about her parenting skills.

The book that promises to put your children to sleep

Exhausted parents from around the world are singing the praises of a "miracle" book which promises to put even the most restless child to sleep in just minutes.

5 things every parent who feels guilty needs to know

Parenthood can make you feel bad, but you're not alone.

Royals criticise 'dangerous' attempts to photograph Prince George

The British royal family criticized paparazzi on Friday for what it called their increasingly dangerous attempts to photograph young Prince George.

'No jab, no play' rule to cover Victorian kindergartens and childcare centres

"Anti-vaxxers" face not being able to send their children to childcare centres or kindergarten if they refuse to have them immunised.

15,000 birthing kits on their way to developing countries

Giving birth in a hospital surrounded by medical experts is tough enough, but some women deliver babies without a clean sheet to lie on.

Photo of premmie 'too graphic', fundraising site says

When their son Jacob was born at just 27 weeks, Christina and Jeff Hinks were thrown into an uncertain world.

The latest Bugaboo collections: cool chevron and runner prams

Bugaboo sure likes to keep things fresh, and with the Australian spring/summer season coming up, there are two new Bugaboo pram releases.

Making room for two in the bed

Mum's room or their own room? Cot or bassinets? Deciding where twins will sleep can be tricky.

 

FREE TICKET

See Hi-5 LIVE in Sydney!

Get your free ticket to The Essential Baby & Toddler Show and save $20 - register online now!

 
Advertisement
 
 
Essential Baby and Essential Kids is the place to find parenting information and parenting support relating to conception, pregnancy, birth, babies, toddlers, kids, maternity, family budgeting, family travel, nutrition and wellbeing, family entertainment, kids entertainment, tips for the family home, child-friendly recipes and parenting. Try our pregnancy due date calculator to determine your due date, or our ovulation calculator to predict ovulation and your fertile period. Our pregnancy week by week guide shows your baby's stages of development. Access our very active mum's discussion groups in the Essential Baby forums or the Essential Kids forums to talk to mums about conception, pregnancy, birth, babies, toddlers, kids and parenting lifestyle. Essential Baby also offers a baby names database of more than 22,000 baby names, popular baby names, boys' names, girls' names and baby names advice in our baby names forum. Essential Kids features a range of free printable worksheets for kids from preschool years through to primary school years. For the latest baby clothes, maternity clothes, maternity accessories, toddler products, kids toys and kids clothing, breastfeeding and other parenting resources, check out Essential Baby and Essential Kids.