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Help with going fowards after 2 Missed MC
Any suggestions welcome

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#1 hillplain

Posted 04 December 2012 - 09:22 PM

Hi Ladies - I posted this over in the pregnancy after loss and recieved 140 views but only 1 response. I hope that someone here may be able to help me.

For those of you who don't know me my story goes a little like this.
We have done 2 IVF ICSI HA cycles. Both with a BFP - however....
Cycle 1 - heartbeat detected at nearly 7 weeks and all seemed fine until I started to spot and eventually MC at nearly 12 weeks. Scan before MC showed around 7 weeks. D&C to 'help'. Results from this all fine - nothing shown up.
Cycle 2 - heartbeat detected at 7 weeks. On eostregen patches, progesterone x 2 daily and baby asprin. Saw OB at start of week 8 - Monday OB says nothing to worry about. Good strong heartbeat levels all fine. Wed early morning had horrible pain but just thought it was gas? As heading to New Zealand for work I pushed for another US the day before 9 weeks. No heartbeat detected. Sac measuring 7.5 weeks. D&C done Sat morning before flying out to New Zealand. Yet to get test results back.
So we have an appointment with FS next Monday.
I am also a poor responder and have only a low egg collection and growth rate. Both ET have been day 3 as there has only been 2 eggs with the second one fragmenting by day 3.
I guess a lot of people say that after 3 MC that they start testing but I don't know if I can go through this now repeated pattern again. I would like to push for further testing as this cycle has cost us in excess of $16k (without rebates 10k after) due to travel, DH time away from contracting and paying someone to look after farm. Each cycle is quite stressful in addition to just the IVF.
Can anyone provide me with some direction or questions that may be helpful to discuss with specialist?
I will thank you wonderful ladies in advance for your time.

#2 bree18

Posted 06 December 2012 - 07:37 PM

So sorry about your losses. I'm currently going through my second IVF loss in a row and feeling a bit discouraged about going through another cycle just to miscarry again. Is your FS a recurrent miscarraige specialist? I know some have special interest in this area. My only other suggestion would be asking your FS about PGD (preimplantation genetic diagnosis) as I know there are a few ladies in the IVF PGD buddy group doing PGD for recurrent miscarriage. I think normally they test the embryos for chromosomal issues, not sure if this would be appropriate in your case if you testing results have shown no chromosomal problems but talk to your FS about it as they may test for other issues too. I use PGD to screen embryos for a genetic condition I carry.
Not sure if this is helpful but it might be worth looking into.

#3 Satay Chicken

Posted 07 December 2012 - 10:20 AM

Hi Hillplain - so sorry that you are going through this...

I know you mentioned that you are struggling with the tests and the cost, which I totally understand, but is there any way you might consider asking your FS for some immune testing?  Immune testing (for NK cells) would involve a blood test - which is covered by Medicare so no cost, only thing is that you need to get to Kogarah in Sydney for that test - even if you cannot get to Sydney, the biopsy might be enough anyway..  Then there is also a uterine biopsy, while uncomfortable only takes 1 minute, it will set you back about $280 and you would require a break month to do this, I think I got $140 back from Medicare for the biopsy.

Considering these tests cost so little, you get the results back quickly and if your levels are over, are easily treated easy medication (Prednisolone, about $10 and Clexane about $40 - cost each two weeks).
I know there is also PGD but that comes at a huge cost and I am so glad I did immune testing before ever considering PGD, which wouldn't have even worked for me anyway.

If you every want to know anything more by all means pop me a PM...  wink.gif
Take care ok Hillplain...

#4 ~lollies~

Posted 07 December 2012 - 10:48 AM

Hi Hillplain

Sorry to hear of your losses.

I've had 7 losses (3 missed miscarriages between 8-11 weeks and 4 chemicals/ early losses) and am now 27 weeks into my 8th pregnancy and going strong.

I agree with Satay Chicken in regards to NK cell testing and IVF with PGD.  

IVF with PGD is what finally worked for us along with the Prednisone and clexane for NK cells.  We only got 4 eggs/embryos but 3 out of the 4 had chromosome issues and the one lucky one is kicking me daily.

FYI - We tested negatively for NK Cells with the blood test but positively for the uterine test so it pays to get both done.

Good luck, I sincerely hope this loss is your last. original.gif

#5 Feral-as-Meggs

Posted 07 December 2012 - 12:41 PM

So sorry for your losses.

My FS ordered the full range of recurrent miscarriage screening including karyotyping for me after 2 losses, when I was doing IVF.  But even if you had to pay privately, it might be better than doing another cycle with unanswered questions.

The other thing we did was a uterine biopsy and I had a chronic infection bubbling along in there (no symptoms at all) so we treated that.  She doesnt really believe in NK cells but would have let me try the steroids/clexane if I wanted to.  

I also had a fibroid which was techically under the size where it would cause problems, but I had it removed after the losses and the next cycle was successful.  But who knows if that was the cause.  My FS felt it was just a case of when I got the "right embryo" it would stick.

She told me that the next step would have been PGD.  

Hopefully you can have a good talk with your FS and make a plan, and you have a sticky one soon.

#6 Madalem

Posted 07 December 2012 - 08:07 PM

Hi Hillplain......sorry for your losses....

I'm one of the ladies who Bree was talking about who is doing PGD for recurrent miscarriage.....

I'll PM you some info about my journey that you might find helpful.....

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