Jump to content

Whooping cough help - IgG, IgA and IgM confusion


  • Please log in to reply
5 replies to this topic

#1 ~~~

Posted 24 November 2012 - 11:56 AM

Hi All,
Well, I have just been diagnosed with my third bout of whooping cough in 12mths......  sad.gif
Yes, I've had the booster about 3yrs ago and I'm now more than a bit concerned about what is going on.

I'm also 6mths pregnant and this is my second time this pregnancy that I need to take stronger antibiotics due to WC diagnosis.

My question is, what is the difference between the IgG, IgA and IgM serologies? My OB wanted to know what my IgM was but it wasn't done in this blood test - they only did IgA and IgG (both of which are showing "detected" as the result).

Any immunologists or microbiologists out there that can help clarify?

Its not like I have been coughing for 12mths straight, and after ABs, the symptoms do eventually go. I am just confused as to whether the serology results are because of previous exposures/infections or if I am being treated unnecessarily (basically). I don't want to risk passing this nasty disease on to anyone else.

Thanks

Edited by ~~~, 24 November 2012 - 12:02 PM.


#2 nen-c

Posted 24 November 2012 - 12:09 PM

Doesn't sound like a good situation OP - there is more info at the following sites - the 2nd site claims to be peer reviewed and appears professional, but I've no idea if that is actually the case or not.

I hope you feel better soon.

http://www0.health.nsw.gov.au/factsheets/g...e/pertusis.html

and here

https://labtestsonline.org/understanding/an...tussis/tab/test

#3 ~~~

Posted 24 November 2012 - 12:24 PM

Thanks nen-c, I had seen that second site.

With further reading, I guess its more a specific question of how long would IgA be detectable after infection? If its only detectable in the first few weeks, not months, then this would be a new infection, rather than just a viral or other infection.

I've just had the nasal swab done today to see if it is positive as well. Last one I had was negative for the swab and positive/equivocal for the bloods.

Edited by ~~~, 24 November 2012 - 12:25 PM.


#4 Duck-o-lah

Posted 24 November 2012 - 03:50 PM

Pretty graph from this article.

Having a quick scroll through, seems the thinking is that using IgA and IgG to diagnose BP is not much more useful than using IgG alone, although this is controversial. Where I work we used to test for IgA however we now use an immunoassay for IgG only. I'm really not sure about IgM. I'll see if I can remember to ask my boss for more details on Monday.

Poor you, I hope they can clarify things for you quickly original.gif

Edited by duck-o-lah, 24 November 2012 - 03:52 PM.


#5 niggles

Posted 24 November 2012 - 04:13 PM

My immunology doesn't get used much these days so I'm a little rusty but for what it's worth.

IgA, IgG and IgM are different forms of antibodies.

Some types of antibodies, like IgG, are present all the time in your blood after you have been exposed to that particular microbe either through infection or vaccination. Testing for this can tell you whether someone is immune to a disease, or at least that they've been exposed to it at some stage.

IgM tends to be present following a current or recent infection and then it drops off again.

My guess is your OB wants to know whether you have had a recent exposure to the disease, or have an active infection as opposed to your current status of immunity against the diesase.

I'm not too sure on the diagnostic relevance of IgA here. It's usual role is in secretions like mucous and saliva.

#6 Angelina Ballerina

Posted 24 November 2012 - 04:19 PM

What niggles said




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users

 

Decluttering before Christmas: tips for managing the toy influx

Deciding how many toys you want to keep and enforcing a limit can help manage the sheer volume of playthings.

86-year-old taught himself to knit, now makes caps for premature babies

'Anything is possible if you put your mind to it' might just be the motto of 86 year-old retiree, Ed Moseley who despite his age and abilities has been gifting handmade knitted caps to premature babies.

Want healthy kids? Let them play in the mud, feed them allergenic foods - and get a dog

If you read about children's health, you've heard a lot of this before.

Photo captures mum's shock at delivery room surprise

Life can be full of surprises, but for this couple a surprise came in a very unexpected way.

Baby's family in law suit over RAAF base chemicals

A 10-month-old baby has been exposed to significant levels of toxic chemicals around a RAAF base near Newcastle, say his parents.

Childcare worker investigated after threatening toddler's mother

An early childhood teacher has been censured for serious misconduct after she threatened the mother of a young child.

Scottish baby names

Scotland, the wind and water-hewn land of the loch, the kilt and the heather. Bedecked in castles great and small, there are many Australians with Scottish heritage who could look to that fair country for baby name inspiration.

Do we need more parking spaces for parents?

The Give Me Space campaign is collecting stories from mums who have had difficult experiences while trying to find safe parking.

Gender neutral parenting: what it's really like

If you want to take a leaf out of Clare's book in gender neutral parenting, her advice is simple: "Follow the children's lead, and you can't go wrong."

The vital question no parent wants to think about

Since becoming a mother I sometimes wonder what would happen to my babies if their dad and I both died.

6 parents to stop judging right now

It's worth looking a little more closely at some common parenting missteps. Could it be these mums and dads are really just like you and me?

Ryan Reynolds shares delivery room tips for expectant dads

If your partner is heading to the delivery room any time soon, you've got to see Ryan Reynolds' video on dealing with the intricacies of the delivery room.

The trials and tribulations of teenage mums, 10 years later

Having her first baby at 16 was a shock for Simone Miller, but it's not something she regrets.

Grandma falls head over heels for baby - literally

Usually Valerie Sharp's plan to put her granddaughter into her cot works just fine, but when things go wrong it is hilarious.

My toddler wants all my attention all of the time - help!

This is a stage, and you and she will move through it. I can (almost) promise it.

Cotton On KIDS' cute new baby prewalker shoes

Oh watch out folks, Cotton On KIDS' baby range has just become even cuter with the release of its first ever prewalker shoe collection.

Why I love the superhero phase

My twins are heading towards three and have officially entered the superhero phase. It happened almost overnight.

I'm caught in a 'mumpetition' with my friend and I'm losing it

My best friend and I had children within a year of each other. She thinks her child is God's gift to the world.

A year of motherhood: my survival story

Motherhood burns you down, but it rebuilds you too.

Five traps to be aware of when reading IVF clinic websites

Clinics provide IVF success rates in often confusing ways because there is no agreed format on how this information should be presented.

 
Advertisement
 

Top 5 Articles

Advertisement
 
 
 

What's hot on EB

What pregnancy is really like: mums share their honest opinions

We asked real women what surprised them during their pregnancy. They've shared their experiences in the hope of preparing the rest of us better for the ride

The truth about big-headed babies

Research suggests that big headed babies become more intelligent than their smaller peers. One mum shares the positives and negatives of having a big headed baby.

How to encourage your baby's gross motor development skills

There are some everyday things that parents can do to improve gross motor skills and coordination.

'My baby's extra thumb saved her life'

A mum whose daughter was born with an extra thumb says that the extra digit saved her life.

He gave her his liver, she gave him her heart

Heather Krueger and Chris Dempsey's origin story began in a darker place than most: with stage 4 liver cancer.

Toilet training from birth? It is possible

This method, called elimination communication (EC or assisted infant toilet training), is becoming increasingly popular in the West.

Watch hilarious montage of strangest pregnancy questions on Yahoo Answers

Some of the strangest questions about pregnancy - and some of the most bizarre spelling - have made for a hilarious video.

How to reduce your chances of perineal tearing in birth

The use of heat packs, along with other aspects of clinical care, can reduce your risk of tearing in birth.

 

Baby Names

Unusual Celeb Baby Names

Click through the gallery to read the details and see some of the most memorable monikers in show biz families.

 
Advertisement
 
 
Essential Baby and Essential Kids is the place to find parenting information and parenting support relating to conception, pregnancy, birth, babies, toddlers, kids, maternity, family budgeting, family travel, nutrition and wellbeing, family entertainment, kids entertainment, tips for the family home, child-friendly recipes and parenting. Try our pregnancy due date calculator to determine your due date, or our ovulation calculator to predict ovulation and your fertile period. Our pregnancy week by week guide shows your baby's stages of development. Access our very active mum's discussion groups in the Essential Baby forums or the Essential Kids forums to talk to mums about conception, pregnancy, birth, babies, toddlers, kids and parenting lifestyle. Essential Baby also offers a baby names database of more than 22,000 baby names, popular baby names, boys' names, girls' names and baby names advice in our baby names forum. Essential Kids features a range of free printable worksheets for kids from preschool years through to primary school years. For the latest baby clothes, maternity clothes, maternity accessories, toddler products, kids toys and kids clothing, breastfeeding and other parenting resources, check out Essential Baby and Essential Kids.