When we think about the difficulties of colonising another planet, the last thing we probably worry about about is sex. However, for our species to survive beyond Earth it's a fundamental issue. While no astronauts have admitted having sex in space, plenty of reproduction has been going on.
This is because a range of animals from fruit flies to fish – as well as their eggs, sperm and embryos – have been sent into space so we can study how they reproduce. While these studies indicate that the first stages of reproduction in space are possible, other research suggests that lower gravity may slow down the development of the embryo.
Many of these studies have been based on IVF using sperm and eggs in orbit. Embryos and already pregnant animals have also been sent to space. However, we have yet to see the entire process of an animal in space getting pregnant, going through a normal pregnancy and having healthy babies up there, so there is still a long way to go.
Of particular interest to space agencies, astronauts and scientists are the effects of radiation on reproduction. Space is full of highly energetic particles which can damage our DNA. On Earth, thanks to our atmosphere, our exposure to this type of radiation is about 100 times lower than at the International Space Station (ISS). Now a new study, published in PNAS, has investigated the effects of space radiation on male reproduction by blasting mouse sperm up to the ISS.
The first issue for the researchers was how best to get the sperm up there. They decided to have the sperm freeze-dried, just like instant coffee. This meant the sperm weighed almost nothing and could be kept at room temperature, ideal for travel on a rocket, or a distant planet. The mouse sperm then spent 288 days on the ISS before coming back to Earth to be compared with fresh sperm from the same mice.
First the scientists analysed how space travel affected the integrity of the DNA within the sperm. We know that high levels of fragmentation of sperm DNA is associated with male infertility. As expected, the scientists discovered that the space sperm had higher amounts of fragmented DNA than the sperm which had stayed on Earth. However, when used to fertilise a mouse egg, the space sperm resulted in a similar number of healthy embryos being generated – and these offspring had the ability to develop into normal, fertile adult mice. A final test the researchers did was to compare the patterns of genes being expressed within the brains of the adult mice. Here, the researchers saw no overall differences and concluded the space sperm were equally capable of generating offspring.
The minimal effect on fertility in these highly controlled studies seems to match observations on the fertility of astronauts coming back from space. However, this is the first study to look directly at how space travel damages sperm.
So it seems short-term space travel is OK for sperm quality. It somehow seemed that the damaged space sperm was "repaired" when fertilising the egg, which was from young, healthy mice. This suggests eggs can compensate for sperm of poorer quality, mending damaged DNA and ensuring the development of the embryo. However, it would be interesting to see whether eggs, which have been into space, would also mend poor quality sperm just as well.